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Shin Heng Chiou
Researcher at Stanford University
Publications - 24
Citations - 2326
Shin Heng Chiou is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & Metastasis. The author has an hindex of 16, co-authored 24 publications receiving 1561 citations. Previous affiliations of Shin Heng Chiou include Howard Hughes Medical Institute & National Taiwan University.
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Journal ArticleDOI
Organoid Modeling of the Tumor Immune Microenvironment.
James T. Neal,Xingnan Li,Junjie Zhu,Valeria Giangarra,Caitlin L. Grzeskowiak,Jihang Ju,Iris H. Liu,Shin Heng Chiou,Ameen A. Salahudeen,Amber R. Smith,Brian C. Deutsch,Lillian Liao,Allison Zemek,Fan Zhao,Kasper Karlsson,Liora M. Schultz,Thomas J. Metzner,Lincoln Nadauld,Yuen-Yi Tseng,Sahar Alkhairy,Coyin Oh,Paula Keskula,Daniel Mendoza-Villanueva,Francisco M. De La Vega,Pamela L. Kunz,Joseph C. Liao,John T. Leppert,John B. Sunwoo,Chiara Sabatti,Jesse S. Boehm,William C. Hahn,William C. Hahn,Grace X.Y. Zheng,Mark M. Davis,Mark M. Davis,Calvin J. Kuo +35 more
TL;DR: Air-liquid interface method propagated patient-derived organoids (PDOs) from >100 human biopsies or mouse tumors in syngeneic immunocompetent hosts as tumor epithelia with native embedded immune cells to enable immuno-oncology investigations within the TME and facilitate personalized immunotherapy testing.
Journal ArticleDOI
Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
Sarah K. Denny,Dian Yang,Chen-Hua Chuang,Jennifer J. Brady,Jing Shan Lim,Barbara M. Grüner,Shin Heng Chiou,Alicia N. Schep,Jessika Baral,Cécile Hamard,Martine Antoine,Marie Wislez,Christina S. Kong,Andrew J. Connolly,Kwon-Sik Park,Julien Sage,William J. Greenleaf,Monte M. Winslow +17 more
TL;DR: The identification of widespread chromatin changes during SCLC progression reveals an unexpected global reprogramming during metastatic progression, and indicates that Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions.
Journal ArticleDOI
Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing
Shin Heng Chiou,Ian P. Winters,Jing Wang,Santiago Naranjo,Crissy Dudgeon,Fiona B. Tamburini,Jennifer J. Brady,Dian Yang,Barbara M. Grüner,Chen-Hua Chuang,Deborah R. Caswell,Hong Zeng,Pauline Chu,Grace E. Kim,Darren R. Carpizo,Darren R. Carpizo,Seung K. Kim,Monte M. Winslow +17 more
TL;DR: It is demonstrated that retrograde pancreatic ductal injection of either adenoviral-Cre or lentiviral- Cre vectors allows titratable initiation of pancreatic neoplasias that progress into invasive and metastatic PDAC.
Journal ArticleDOI
Gpr124 is essential for blood–brain barrier integrity in central nervous system disease
Junlei Chang,Michael R. Mancuso,Carolina M. Maier,Xibin Liang,Kanako Yuki,Lu Yang,Jeffrey W. Kwong,Jing Wang,Varsha Rao,Mario Vallon,Cynthia Kosinski,J J Haijing Zhang,Amanda T. Mah,Lijun Xu,L Li,Sharareh Gholamin,Teresa F Reyes,Rui Li,Frank Kuhnert,Xiaoyuan Han,Jenny Yuan,Shin Heng Chiou,Ari D Brettman,Lauren Daly,David C Corney,Samuel H. Cheshier,Linda D. Shortliffe,Xiwei Wu,Michael Snyder,Pak H. Chan,Rona G. Giffard,Howard Y. Chang,Katrin I. Andreasson,Calvin J. Kuo +33 more
TL;DR: Gpr124 is identified as an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity under pathological conditions in adult mice, which implicates Gpr124 as a potential therapeutic target for human CNS disorders characterized by BBB disruption.
Journal ArticleDOI
Comprehensive T cell repertoire characterization of non-small cell lung cancer
Alexandre Reuben,Jiexin Zhang,Shin Heng Chiou,Rachel M. Gittelman,Jun Li,Won-Chul Lee,Junya Fujimoto,Carmen Behrens,Xiaoke Liu,Feng Wang,Kelly Quek,Chunlin Wang,Farrah Kheradmand,Runzhe Chen,Chi Wan Chow,Heather Lin,Chantale Bernatchez,Ali Jalali,Xin Hu,Chang-Jiun Wu,Agda Karina Eterovic,Edwin R. Parra,Erik Yusko,Ryan O. Emerson,Sharon Benzeno,Marissa Vignali,Xifeng Wu,Yuanqing Ye,Latasha Little,Curtis Gumbs,Xizeng Mao,Xingzhi Song,Samantha Tippen,Rebecca Thornton,Tina Cascone,Alexandra Snyder,Jennifer A. Wargo,Roy S. Herbst,Stephen G. Swisher,Humam Kadara,Cesar A. Moran,Neda Kalhor,Jianhua Zhang,Paul Scheet,Ara A. Vaporciyan,Boris Sepesi,Don L. Gibbons,Harlan Robins,Patrick Hwu,John V. Heymach,Padmanee Sharma,James P. Allison,Veera Baladandayuthapani,Jack Lee,Mark M. Davis,Ignacio I. Wistuba,P. Andrew Futreal,Jianjun Zhang +57 more
TL;DR: It is shown, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of Tcell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.