C
Christine C. Winterbourn
Researcher at University of Otago
Publications - 217
Citations - 22780
Christine C. Winterbourn is an academic researcher from University of Otago. The author has contributed to research in topics: Hypochlorous acid & Myeloperoxidase. The author has an hindex of 72, co-authored 211 publications receiving 20079 citations. Previous affiliations of Christine C. Winterbourn include Health Science University & Gravida.
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Reconciling the chemistry and biology of reactive oxygen species
TL;DR: This review examines how target selectivity and antioxidant effectiveness vary for different oxidants and highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling.
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Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.
TL;DR: Neutrophils are one of the professional phagocytes in humans that ingest bacteria into intracellular spaces and are involved in phagocytosis.
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Thiol chemistry and specificity in redox signaling.
TL;DR: This review focuses on mechanisms for sensing and transmitting redox signals, from the perspective of their chemical reactivity with specific oxidants, and discusses substrate preferences for different oxidants and how the kinetics of these reactions determines how each oxidant will react in a cell.
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Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide.
TL;DR: With superoxide, the results are consistent with each thiol reacting via a short chain that consumes oxygen and regenerates superoxide and the consumed oxygen recovered as hydrogen peroxide.
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Unraveling the biological roles of reactive oxygen species.
Michael P. Murphy,Arne Holmgren,Nils-Göran Larsson,Barry Halliwell,Christopher J. Chang,Balaraman Kalyanaraman,Sue Goo Rhee,Paul J. Thornalley,Linda Partridge,David Gems,Thomas Nyström,Vsevolod V. Belousov,Paul T. Schumacker,Christine C. Winterbourn +13 more
TL;DR: Significant progress is being made in addressing reactive oxygen species and oxidative damage in biological systems, and here is a survey of some recent developments.