C
Christine Haugen
Researcher at Haukeland University Hospital
Publications - 7
Citations - 1240
Christine Haugen is an academic researcher from Haukeland University Hospital. The author has contributed to research in topics: Adipose tissue & Rank correlation. The author has an hindex of 5, co-authored 6 publications receiving 1019 citations. Previous affiliations of Christine Haugen include University of Bergen & University of Gothenburg.
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Journal ArticleDOI
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
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The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss.
Vivian L. Veum,Simon N. Dankel,Simon N. Dankel,Jennifer Gjerde,Jennifer Gjerde,Hans Jørgen Nielsen,Margit H. Solsvik,Margit H. Solsvik,Christine Haugen,Bjørn Jostein Christensen,Bjørn Jostein Christensen,Tuyen Hoang,Tuyen Hoang,Dag Fadnes,Christian Busch,Villy Våge,Jørn V. Sagen,Jørn V. Sagen,Gunnar Mellgren,Gunnar Mellgren +19 more
TL;DR: Altered adipose tissue expression of the NR4As in obesity is shown, suggesting that these stress responsive nuclear receptors may modulate pathogenic potential in humans.
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Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice
Simon N. Dankel,Eirik Degerud,Kamil Borkowski,Kamil Borkowski,Even Fjære,Even Fjære,Lisa Kolden Midtbø,Lisa Kolden Midtbø,Christine Haugen,Margit H. Solsvik,Margit H. Solsvik,Anne-Marie Lavigne,Anne-Marie Lavigne,Bjørn Liaset,Bjørn Liaset,Jørn V. Sagen,Karsten Kristiansen,Gunnar Mellgren,Gunnar Mellgren,Lise Madsen,Lise Madsen +20 more
TL;DR: Weight-cycled mice were characterized by a downregulation of several clock genes (Dbp, Tef, Per1, Per2, Per3, and Nr1d2) in adipose tissues, which was confirmed by quantitative PCR and suggested that clock genes in adipOSE tissue may play a role in metabolic adaptation to weight cycling.
Journal ArticleDOI
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity
Jan-Inge Bjune,Jan-Inge Bjune,Christine Haugen,Christine Haugen,Oddrun Anita Gudbrandsen,Ole Petter Nordbø,Ole Petter Nordbø,Hans Jørgen Nielsen,Villy Våge,Pål R. Njølstad,Pål R. Njølstad,Jørn V. Sagen,Jørn V. Sagen,Simon N. Dankel,Simon N. Dankel,Gunnar Mellgren,Gunnar Mellgren +16 more
TL;DR: This novel Irx5-App pathway in adipose tissue is a possible therapeutic entry point against obesity and can partially be attributed to reduced adipose App and improved mitochondrial respiration.
Journal ArticleDOI
Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice
Jessica Svärd,Jessica Svärd,Therese H. Røst,Therese H. Røst,Camilla E. N. Sommervoll,Camilla E. N. Sommervoll,Christine Haugen,Christine Haugen,Oddrun Anita Gudbrandsen,Anne E. Mellgren,Anne E. Mellgren,Eyvind Rødahl,Eyvind Rødahl,Johan Fernø,Johan Fernø,Simon N. Dankel,Simon N. Dankel,Jørn V. Sagen,Jørn V. Sagen,Gunnar Mellgren,Gunnar Mellgren +20 more
TL;DR: In this article, the authors investigated the metabolic consequences of loss of decorin in mice (DcnKO) and found evidence that decorin is an important factor for maintaining glucose tolerance.