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Simon N. Dankel
Researcher at University of Bergen
Publications - 53
Citations - 2235
Simon N. Dankel is an academic researcher from University of Bergen. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 15, co-authored 38 publications receiving 1702 citations. Previous affiliations of Simon N. Dankel include Haukeland University Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
Journal ArticleDOI
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes
Siegfried Ussar,Kevin Y. Lee,Simon N. Dankel,Simon N. Dankel,Simon N. Dankel,Jeremie Boucher,Max-Felix Haering,André Kleinridders,Thomas Thomou,Ruidan Xue,Yazmín Macotela,Aaron M. Cypess,Yu-Hua Tseng,Gunnar Mellgren,Gunnar Mellgren,C. Ronald Kahn +15 more
TL;DR: Three new surface markers of white, beige, and brown fat cells are identified using a combination of in silico, in vitro, and in vivo methods to identify and target white and brown/beige adipocytes for therapeutic purposes.
Journal ArticleDOI
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms
Melina Claussnitzer,Simon N. Dankel,Bernward Klocke,Harald Grallert,Viktoria Glunk,Tea Berulava,Heekyoung Lee,Nikolay Oskolkov,João Fadista,Kerstin Ehlers,Simone Wahl,Christoph Hoffmann,Kun Qian,Tina Rönn,Helene Riess,Martina Müller-Nurasyid,Nancy Bretschneider,Timm Schroeder,Thomas Skurk,Bernhard Horsthemke,Derek Spieler,Martin Klingenspor,Martin Seifert,Michael J. Kern,Niklas Mejhert,Ingrid Dahlman,Ola Hansson,Stefanie M. Hauck,Matthias Blüher,Peter Arner,Leif Groop,Thomas Illig,Karsten Suhre,Yi-Hsiang Hsu,Gunnar Mellgren,Hans Hauner,Helmut Laumen +36 more
TL;DR: It is shown that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify cis-regulatory variants and elucidate their mechanistic role in disease.
Journal ArticleDOI
Switch from Stress Response to Homeobox Transcription Factors in Adipose Tissue After Profound Fat Loss
Simon N. Dankel,Simon N. Dankel,Dag Fadnes,Anne-Kristin Stavrum,Anne-Kristin Stavrum,Christine Stansberg,Christine Stansberg,Rita Holdhus,Rita Holdhus,Tuyen Hoang,Tuyen Hoang,Vivian L. Veum,Vivian L. Veum,Bjørn Jostein Christensen,Bjørn Jostein Christensen,Villy Våge,Jørn V. Sagen,Jørn V. Sagen,Vidar M. Steen,Vidar M. Steen,Gunnar Mellgren,Gunnar Mellgren +21 more
TL;DR: A marked switch of transcription factors in adipose tissue after profound fat loss is demonstrated, providing new molecular insight into a dichotomy between stress response and metabolically favorable tissue development.
Journal ArticleDOI
COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size
Simon N. Dankel,Simon N. Dankel,Jessica Svärd,Jessica Svärd,Simone Matthä,Melina Claussnitzer,Nora Klöting,Viktoria Glunk,Zinayida Fandalyuk,Zinayida Fandalyuk,Elise Grytten,Elise Grytten,Margit H. Solsvik,Margit H. Solsvik,Hans-Jørgen Nielsen,Christian Busch,Hans Hauner,Matthias Blüher,Thomas Skurk,Jørn V. Sagen,Jørn V. Sagen,Gunnar Mellgren,Gunnar Mellgren +22 more
TL;DR: A role for human adipocytes linking COL6A3 with insulin resistance warrants exploration and may modulate adipose tissue function in obesity and insulin resistance.