C
Christine L. Chaffer
Researcher at Garvan Institute of Medical Research
Publications - 42
Citations - 13315
Christine L. Chaffer is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Stem cell & Cancer. The author has an hindex of 26, co-authored 33 publications receiving 11398 citations. Previous affiliations of Christine L. Chaffer include Monash Institute of Medical Research & University of Melbourne.
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Journal ArticleDOI
A Perspective on Cancer Cell Metastasis
TL;DR: It is suggested that metastasis can be portrayed as a two-phase process: the first phase involves the physical translocation of a cancer cell to a distant organ, whereas the second encompasses the ability of the cancer cellto develop into a metastatic lesion at that distant site.
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Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.
David van Dijk,Roshan Sharma,Roshan Sharma,Juozas Nainys,Juozas Nainys,Kristina Yim,Pooja Kathail,Pooja Kathail,Ambrose J. Carr,Ambrose J. Carr,Cassandra Burdziak,Kevin R. Moon,Christine L. Chaffer,Diwakar R. Pattabiraman,Brian Bierie,Linas Mazutis,Guy Wolf,Smita Krishnaswamy,Dana Pe'er +18 more
TL;DR: MAGIC as mentioned in this paper is a Markov affinity-based graph imputation of cells that shares information across similar cells, via data diffusion, to denoise the cell count matrix and fill in missing transcripts.
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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
Christine L. Chaffer,Ines Brueckmann,Christina Scheel,Alicia J. Kaestli,Paul A. Wiggins,Leonardo O. Rodrigues,Mary W. Brooks,Ferenc Reinhardt,Ying Su,Kornelia Polyak,Lisa M. Arendt,Charlotte Kuperwasser,Brian Bierie,Robert A. Weinberg +13 more
TL;DR: It is demonstrated that normal and CSC-like cells can arise de novo from more differentiated cell types and that hierarchical models of mammary stem cell biology should encompass bidirectional interconversions between stem and nonstem compartments.
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Cancer stem cells: mirage or reality?
TL;DR: An examination of the literature indicates that the CSC model rests on firm experimental foundations and that differences in the observed frequencies of CSCs within tumors reflect the various cancer types and hosts used to assay these cells.
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Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.
Christina Scheel,Elinor Ng Eaton,Sophia Hsin-Jung Li,Christine L. Chaffer,Ferenc Reinhardt,Kong Jie Kah,George W. Bell,Wenjun Guo,Jeffrey S. Rubin,Andrea L. Richardson,Robert A. Weinberg +10 more
TL;DR: In this article, the authors describe three signaling pathways, involving transforming growth factor (TGF)-β and canonical and noncanonical Wnt signaling, that collaborate to induce activation of the EMT program and thereafter function in an autocrine fashion to maintain the resulting mesenchymal state.