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Yong-Gui Gao
Researcher at Nanyang Technological University
Publications - 70
Citations - 2980
Yong-Gui Gao is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Ribosome & Translation (biology). The author has an hindex of 21, co-authored 66 publications receiving 2366 citations. Previous affiliations of Yong-Gui Gao include Institute of Molecular and Cell Biology & Zhejiang University.
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Journal ArticleDOI
The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA.
T. Martin Schmeing,Rebecca M. Voorhees,Ann C. Kelley,Yong-Gui Gao,Frank V. Murphy,John R. Weir,Venki Ramakrishnan +6 more
TL;DR: Crystal structures of the ribosome bound to elongation factors provide insights into translocation and decoding, and a series of conformational changes in EF-Tu and aminoacyl-tRNA suggests a communication pathway between the decoding center and the guanosine triphosphatase center of EF- Tu.
Journal ArticleDOI
The structure of the ribosome with elongation factor G trapped in the posttranslocational state.
Yong-Gui Gao,Maria Selmer,Christine M. Dunham,Albert Weixlbaumer,Ann C. Kelley,Venki Ramakrishnan +5 more
TL;DR: A crystal structure refined to 3.6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid is reported, providing insights into translocation and decoding.
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The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
Cajetan Neubauer,Yong-Gui Gao,Kasper R. Andersen,Christine M. Dunham,Ann C. Kelley,Jendrik Hentschel,Kenn Gerdes,Venki Ramakrishnan,Ditlev E. Brodersen +8 more
TL;DR: Crystal structures of E. coli RelE in isolation and bound to programmed Thermus thermophilus 70S ribosomes before and after cleavage provide detailed insight into the translational regulation on the bacterial ribosome by mRNA cleavage.
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans
Luang Xu,Liu Xinyu,Na Sheng,Kyaw Soe Oo,Junxin Liang,Yok Hian Chionh,Juan Xu,Fuzhou Ye,Yong-Gui Gao,Peter C. Dedon,Peter C. Dedon,Xin-Yuan Fu,Xin-Yuan Fu +12 more
TL;DR: These findings provide the first evidence of the existence ofm3C modification in mRNA, and the discovery of METTL8 as an mRNA m3C writer enzyme opens the door to future studies of other m 3C epitranscriptomic reader and eraser functions.
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Structure of bacterial cellulose synthase subunit D octamer with four inner passageways
Song-Qing Hu,Yong-Gui Gao,Yong-Gui Gao,Kenji Tajima,Naoki Sunagawa,Yong Zhou,Shin Kawano,Takaaki Fujiwara,Takanori Yoda,Daisuke Shimura,Yasuharu Satoh,Masanobu Munekata,Isao Tanaka,Min Yao +13 more
TL;DR: The cellulose synthesizing terminal complex in Acetobacter xylinum spans the outer and inner cell membranes to synthesize and extrude glucan chains, which are assembled into subelementary fibrils and further into a ribbon.