Journal ArticleDOI
Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
S. J. Creely,S. J. Creely,Philip G. McTernan,Christine M. Kusminski,Ff M. Fisher,N. F. da Silva,M. Khanolkar,Marc Evans,Alison L. Harte,Sudhesh Kumar,Sudhesh Kumar +10 more
TLDR
T2DM is associated with increased endotoxemia, with AT able to initiate an innate immune response, and increased adiposity may increase proinflammatory cytokines and therefore contribute to the pathogenic risk of T2DM.Abstract:
Type 2 diabetes (T2DM) is associated with chronic low-grade inflammation. Adipose tissue (AT) may represent an important site of inflammation. 3T3-L1 studies have demonstrated that lipopolysacchari...read more
Citations
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Functional interactions between the gut microbiota and host metabolism
TL;DR: Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, the world will be in a better position to develop treatments for metabolic disease.
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Macrophages, Inflammation, and Insulin Resistance
TL;DR: Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.
Journal ArticleDOI
The cellular and signaling networks linking the immune system and metabolism in disease
Olivia Osborn,Jerrold M. Olefsky +1 more
TL;DR: This work discusses how various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.
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Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
Luca Miele,Venanzio Valenza,Giuseppe La Torre,Massimo Montalto,Giovanni Cammarota,Riccardo Ricci,Roberta Mascianà,Alessandra Forgione,M.L. Gabrieli,Germano Perotti,Fabio Maria Vecchio,Gian Lodovico Rapaccini,Giovanni Gasbarrini,Christopher P. Day,Antonio Grieco +14 more
TL;DR: In patients with NAFLD, both gut permeability and the prevalence of SIBO correlated with the severity of steatosis but not with presence of NASH, and the increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine.
Journal ArticleDOI
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome.
Eléonore Maury,Sonia Brichard +1 more
TL;DR: Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome.
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