C
Christine Silvain
Publications - 112
Citations - 4334
Christine Silvain is an academic researcher. The author has contributed to research in topics: Cirrhosis & Hepatitis C. The author has an hindex of 30, co-authored 102 publications receiving 3494 citations.
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Journal ArticleDOI
Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial
Valérie Vilgrain,Valérie Vilgrain,Helena Pereira,Eric Assenat,Boris Guiu,Alina Diana Ilonca,Georges-Philippe Pageaux,Annie Sibert,Mohamed Bouattour,Rachida Lebtahi,Wassim Allaham,Hélène Barraud,Valérie Laurent,Elodie Mathias,Jean-Pierre Bronowicki,Jean-Pierre Tasu,Rémy Perdrisot,Christine Silvain,René Gerolami,Olivier Mundler,Jean-François Seitz,Vincent Vidal,Christophe Aubé,Frédéric Oberti,Olivier Couturier,Isabelle Brenot-Rossi,Jean-Luc Raoul,Anthony Sarran,Charlotte Costentin,Emmanuel Itti,Alain Luciani,Alain Luciani,René Adam,Maïté Lewin,Didier Samuel,Maxime Ronot,Maxime Ronot,Aurelia Dinut,Laurent Castera,Laurent Castera,Gilles Chatellier,Gilles Chatellier,Elisabeth Delhom Christol,Alina D. Ilonca,Julie Lonjon,Mohamed Abdel-Rehim,Arnaud Dieudonné,Christophe Bazin,Carine Chagneau-Derrode,Patrick Borentain,Antoine Bouvier,Laurent Vervueren,Julia Chalaye,Hicham Kobeiter,Julien Edeline,Etienne Garin,Yan Rolland,Isabelle Archambeaud,T. Eugène,Eric Frampas,Christophe Cassinotto,Martine Guyot,Jean-Baptiste Hiriart,Bruno Lapuyade,Julien Vergniol,Philippe Bachellier,Julien Detour,Bernard Duclos,Michel Greget,Francois Habersetzer,Alessio Imperiale,Philippe Merle,Agnès Rode,Julie Morvan,Eric Nguyen-Khac,Thierry Yzet,G. Baudin,Patrick Chevallier,Abakar Mahamat,Thierry Piche,Micheline Razzouk,Patrick Hillon,Romaric Loffroy,Michel Toubeau,Julie Vincent,Gabriele Barabino,Nadia Bouarioua,Muriel Cuilleron,Marie Ecochard,Nathalie Prevot-Bitot,Vincent Leroy,J. Roux,Christian Sengel,Valérie Bourcier,Nathalie Ganne-Carrié,Olivier Seror,Sylvie Costo,Thong Dao,Jean-Pierre Pelage,Jérôme Dumortier,Francesco Giammarile,Pierre-Jean Valette,Nadia Ghazzar,Olivier Pellerin,Julien Taieb,Pierre Weinmann,Alexandra Heurgue-Berlot,Claude Marcus,Daniele Sommacale,Maria-Angéla Castilla-Lièvre,Sophie Maitre,Lysiane Marthey +111 more
TL;DR: SarAH was a multicentre, open-label, randomised, controlled, investigator-initiated, phase 3 trial done at 25 centres specialising in liver diseases in France to compare the efficacy and safety of sorafenib to that of selective internal radiotherapy in patients with hepatocellular carcinoma.
Journal ArticleDOI
Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications
Pierre Nahon,Pierre Nahon,Valérie Bourcier,Richard Layese,Etienne Audureau,Carole Cagnot,Patrick Marcellin,Dominique Guyader,Hélène Fontaine,Dominique Larrey,Victor de Ledinghen,Denis Ouzan,Fabien Zoulim,Dominique Roulot,Albert Tran,Jean-Pierre Bronowicki,Jean-Pierre Zarski,Vincent Leroy,Ghassan Riachi,Paul Calès,Jean-Marie Péron,Laurent Alric,Marc Bourlière,Philippe Mathurin,Sébastien Dharancy,Jean-Frédéric Blanc,Armand Abergel,Lawrence Serfaty,Ariane Mallat,Jean-Didier Grangé,Pierre Attali,Yannick Bacq,Claire Wartelle,Thong Dao,Yves Benhamou,Christophe Pilette,Christine Silvain,Christos Christidis,Dominique Capron,Brigitte Bernard-Chabert,David Zucman,Vincent Di Martino,Vincent Thibaut,Dominique Salmon,Marianne Ziol,Angela Sutton,Stanislas Pol,Françoise Roudot-Thoraval,Gérard Thiéfin,Sophie Hillaire +49 more
TL;DR: A reduction in critical events, liver-related or not, was confirmed in the CirVir cohort, a prospective study of patients with HCV infection and compensated cirrhosis included in the ANRS cohort who achieved an SVR, to reduce overall mortality and risk of death from liver- related and non-liver-related causes.
Journal ArticleDOI
A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis.
Christophe Corpechot,Olivier Chazouillères,Alexandra Rousseau,Antonia Le Gruyer,François Habersetzer,Philippe Mathurin,Odile Goria,Pascal Potier,Anne Minello,Christine Silvain,Armand Abergel,Maryline Debette-Gratien,Dominique Larrey,Olivier Roux,Jean-Pierre Bronowicki,Jérôme Boursier,Victor de Ledinghen,Alexandra Heurgué-Berlot,Eric Nguyen-Khac,Fabien Zoulim,Isabelle Ollivier-Hourmand,Jean-Pierre Zarski,Gisèle N'Kontchou,Sara Lemoinne,Lydie Humbert,Dominique Rainteau,Guillaume Lefèvre,Luc de Chaisemartin,Sylvie Chollet-Martin,Farid Gaouar,Farid-Hakeem Admane,Tabassome Simon,Raoul Poupon +32 more
TL;DR: Treating patients with primary biliary cholangitis with bezafibrate in addition to ursodeoxycholic acid resulted in a rate of complete biochemical response that was significantly higher than the rate with placebo and ursodespecific acid therapy.
Journal ArticleDOI
Diagnosis of choledocholithiasis: EUS or magnetic resonance cholangiography? A prospective controlled study
Victor de Ledinghen,Robin Lecesne,Jean-Michel Raymond,Véronique Gense,M. Amouretti,Jacques Drouillard,Patrice Couzigou,Christine Silvain +7 more
TL;DR: This preliminary study confirmed EUS as an accurate and noninvasive procedure for the diagnosis of common bile duct stones and suggested MRCP, which had a high sensitivity and high negative predictive value, might be an accurate technique for patients with a contraindication to EUS.
Journal ArticleDOI
Early administration of vapreotide for variceal bleeding in patients with cirrhosis.
Paul Calès,C Masliah,B Bernard,P P Garnier,Christine Silvain,N. Szostak-Talbodec,Jean-Pierre Bronowicki,D Ribard,D Botta-Fridlund,Patrick Hillon,K Besseghir,Didier Lebrec +11 more
TL;DR: In patients with cirrhosis and variceal bleeding, the combination of vapreotide and endoscope treatment is more effective than endoscopic treatment alone as a method of controlling acute bleeding, but the use of combination therapy does not affect mortality rates at 42 days.