Christophe d'Enfert

TL;DR: Recent advances at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans, are explored: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities.

TL;DR: It is shown that leukopenia, but not treatment with corticosteroids, leads to fungal burdens that are transiently increased over those in immunocompetent mice, and that C. glabrata has successfully developed immune evasion strategies enabling it to survive, disseminate, and persist within mammalian hosts.

TL;DR: An experimental model of oral infection is used to probe the host response to diverse C. albicans isolates in vivo and finds dramatic differences in their ability to persist in the oral mucosa, which inversely correlated with the degree and kinetics of immune activation in the host.

TL;DR: The development of a first generation C.Albicans ORFeome, the improvement of overexpression systems and the construction of two new libraries of C. albicans strains overexpressing genes for components of signaling networks, in particular protein kinases, protein phosphatases and transcription factors are reported.

TL;DR: CandidaDB is a database dedicated to the genome of the most prevalent systemic fungal pathogen of humans, Candida albicans that provides tentative functional assignments along with numerous pre-run analyses that can assist the researcher in the evaluation of gene function for the purpose of specific or large-scale analysis.