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Norman Pavelka
Researcher at Agency for Science, Technology and Research
Publications - 50
Citations - 4642
Norman Pavelka is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Candida albicans & Corpus albicans. The author has an hindex of 31, co-authored 50 publications receiving 3994 citations. Previous affiliations of Norman Pavelka include Singapore Immunology Network & University of Milano-Bicocca.
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Journal ArticleDOI
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.
Norman Pavelka,Giulia Rancati,Jin Zhu,William D. Bradford,Anita Saraf,Laurence Florens,Brian W. Sanderson,Gaye Hattem,Rong Li,Rong Li +9 more
TL;DR: It is shown, using quantitative mass spectrometry-based proteomics and phenotypic profiling, that levels of protein expression in aneuploid yeast strains largely scale with chromosome copy numbers, following the same trend as that observed for the transcriptome, and that aneuPLoidy confers diverse phenotypes.
Journal ArticleDOI
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.
Francesca Granucci,Caterina Vizzardelli,Norman Pavelka,Sonia Feau,Maria Persico,Ettore Virzi,Maria Rescigno,Giorgio Moro,Paola Ricciardi-Castagnoli +8 more
TL;DR: It is found that functional interleukin 2 (IL-2) mRNA, which gave rise to IL-2 production, was transiently up-regulated at early time-points after bacterial encounter, which confers unique T cell stimulatory capacity to DCs.
Journal ArticleDOI
Host and Environmental Factors Influencing Individual Human Cytokine Responses
Rob ter Horst,Martin Jaeger,Sanne P. Smeekens,Marije Oosting,Morris A. Swertz,Yang Li,Vinod Kumar,Dimitri A. Diavatopoulos,Anne F.M. Jansen,Heidi Lemmers,Helga Toenhake-Dijkstra,Antonius E. van Herwaarden,Matthijs Janssen,Renate G. van der Molen,Irma Joosten,Fred C.G.J. Sweep,Johannes W. A. Smit,Romana T. Netea-Maier,Mieke M.J.F. Koenders,Ramnik J. Xavier,Ramnik J. Xavier,Jos W. M. van der Meer,Charles A. Dinarello,Charles A. Dinarello,Norman Pavelka,Norman Pavelka,Cisca Wijmenga,Cisca Wijmenga,Richard A. Notebaart,Leo A. B. Joosten,Mihai G. Netea +30 more
TL;DR: A strong impact of non-genetic host factors (e.g., age and gender) on cytokine production and circulating mediators is shown and annual seasonality is found to be an important environmental factor influencing cytokineproduction.
Journal ArticleDOI
Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor
Giulia Rancati,Norman Pavelka,Brian Fleharty,Aaron Noll,Rhonda Trimble,Kendra N. Walton,Anoja Perera,Karen Staehling-Hampton,Chris Seidel,Rong Li,Rong Li +10 more
TL;DR: The results demonstrate the evolvability of even a well-conserved process and suggest that changes in chromosome stoichiometry provide a source of heritable variation driving the emergence of adaptive phenotypes when the cell division machinery is strongly perturbed.
Journal ArticleDOI
Emerging and evolving concepts in gene essentiality.
TL;DR: A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life.