C
Christopher C. Venters
Researcher at University of Pennsylvania
Publications - 5
Citations - 5303
Christopher C. Venters is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Polyadenylation & snRNP. The author has an hindex of 4, co-authored 5 publications receiving 912 citations.
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Journal ArticleDOI
U1 snRNP regulates cancer cell migration and invasion in vitro
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Jingqi Duan,Gideon Dreyfuss +10 more
TL;DR: An unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states is revealed, and U1 is suggested as a potential target for their modulation.
Posted ContentDOI
U1 snRNP regulates cancer cell migration and invasion
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Gideon Dreyfuss +9 more
TL;DR: It is shown that U1 AMO also modulates cancer cells’ phenotype, dose-dependently increasing migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect.
Journal ArticleDOI
U1 snRNP telescripting regulates a size-function-stratified human genome.
Jung-Min Oh,Chao Di,Christopher C. Venters,Jiannan Guo,Chie Arai,Byung Ran So,Anna Maria Pinto,Zhenxi Zhang,Lili Wan,Ihab Younis,Gideon Dreyfuss +10 more
TL;DR: It is proposed that telescripting adds an overarching layer of regulation to size–function-stratified genomes, leveraged by selective intron expansion to rapidly shift gene expression priorities.
Journal ArticleDOI
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells
Byung Ran So,Chao Di,Zhiqiang Cai,Christopher C. Venters,Jiannan Guo,Jung-Min Oh,Chie Arai,Gideon Dreyfuss +7 more
TL;DR: This work captured a complex, comprising U1 and CPA factors (U1-CPAFs), that binds intronic PASs and suppresses PCPA, demonstrating U1's unique role as central regulator of pre-mRNA processing and transcription.
Journal ArticleDOI
U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation
TL;DR: U1's PCPA suppression activity, termed telescripting, is uncovered, as crucial for full-length transcription in thousands of vertebrate genes, providing a general role in transcription elongation control.