Anna Maria Pinto

TL;DR: An unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states is revealed, and U1 is suggested as a potential target for their modulation.

TL;DR: It is shown that U1 AMO also modulates cancer cells’ phenotype, dose-dependently increasing migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect.

TL;DR: It is shown that rapid and transient transcriptional upregulation inherent to neuronal activation physiology creates U1 shortage relative to pre-mRNAs, and additional experiments suggest cotranscriptional PCPA counteracted by U1 association with nascent transcripts, a process the authors term telescripting, ensuring transcriptome integrity and regulating mRNA length.

TL;DR: Findings suggest that a predisposing genetic background may contribute to the observed interindividual clinical variability associated with COVID-19, allowing an evidence-based risk assessment leading to personalized preventive measures and therapeutic options.

TL;DR: First evidence that oral administration of PB (triButyrate®) significantly increases SMN expression in leukocytes of SMA patients is provided, providing a strong rationale to further investigate the effects of PB.