L
Lili Wan
Researcher at University of Pennsylvania
Publications - 34
Citations - 10223
Lili Wan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: snRNP & SMN complex. The author has an hindex of 26, co-authored 34 publications receiving 5498 citations. Previous affiliations of Lili Wan include Howard Hughes Medical Institute.
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Journal ArticleDOI
U1 snRNP regulates cancer cell migration and invasion in vitro
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Jingqi Duan,Gideon Dreyfuss +10 more
TL;DR: An unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states is revealed, and U1 is suggested as a potential target for their modulation.
Posted ContentDOI
U1 snRNP regulates cancer cell migration and invasion
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Gideon Dreyfuss +9 more
TL;DR: It is shown that U1 AMO also modulates cancer cells’ phenotype, dose-dependently increasing migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect.
Journal ArticleDOI
RNA and Disease
TL;DR: The discovery of disease-causing mutations in RNAs is yielding a wealth of new therapeutic targets, and the growing understanding of RNA biology and chemistry is providing new RNA-based tools for developing therapeutics.
Journal ArticleDOI
SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing
Zhenxi Zhang,Francesco Lotti,Kimberly Dittmar,Ihab Younis,Lili Wan,Mumtaz Kasim,Gideon Dreyfuss +6 more
TL;DR: It is shown that SMN deficiency, similar to that which occurs in severe SMA, has unexpected cell type-specific effects on the repertoire of snRNAs and mRNAs, indicating that SMA is a general splicing disease that is not restricted to motor neurons.
Journal ArticleDOI
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
Daisuke Kaida,Michael G. Berg,Ihab Younis,Mumtaz Kasim,Larry N. Singh,Lili Wan,Gideon Dreyfuss +6 more
TL;DR: It is shown that U1 snRNA–pre-mRNA base pairing was required to suppress premature cleavage and polyadenylation from nearby cryptic polyadenyation signals located in introns.