J
Jingqi Duan
Researcher at University of Pennsylvania
Publications - 7
Citations - 3743
Jingqi Duan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & Pseudouridine. The author has an hindex of 6, co-authored 7 publications receiving 1061 citations. Previous affiliations of Jingqi Duan include Peking University.
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Journal ArticleDOI
U1 snRNP regulates cancer cell migration and invasion in vitro
Jung-Min Oh,Christopher C. Venters,Chao Di,Anna Maria Pinto,Lili Wan,Ihab Younis,Zhiqiang Cai,Chie Arai,Byung Ran So,Jingqi Duan,Gideon Dreyfuss +10 more
TL;DR: An unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states is revealed, and U1 is suggested as a potential target for their modulation.
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Structural Mechanism of Substrate RNA Recruitment in H/ACA RNA-Guided Pseudouridine Synthase
TL;DR: Comparing tRNA Psi55 synthase TruB with H/ACA RNP reveals the structural conservation and adaptation between an RNA-guided and stand-alone pseudouridine synthase and provides insight into the guide-independent activity of Cbf5.
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Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase
TL;DR: This work reconstituted functional Saccharomyces cerevisiae H/ACA RNPs with recombinant proteins Cbf5, Nop10, Gar1, and Nhp2 and a two-hairpin H-ACA RNA and revealed significant novel features of eukaryotic H/ ACA RNPs.
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A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange
Byung Ran So,Lili Wan,Zhenxi Zhang,Pilong Li,Eric S. Babiash,Jingqi Duan,Ihab Younis,Gideon Dreyfuss +7 more
TL;DR: It is proposed that SMN–Gemin2 is a versatile hub for RNP exchange that functions broadly in RNA metabolism and its ability to facilitate transactions between different RBPs and RNAs explains its multi-RBP valency and the myriad transcriptome perturbations associated with SMN deficiency in neurodegenerative spinal muscular atrophy.
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Structure of the Shq1–Cbf5–Nop10–Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita
TL;DR: The results suggest that Shq1 functions as an assembly chaperone that protects the Cbf5 protein complexes from non‐specific RNA binding and aggregation before assembly of H/ACA RNA.