Xiao-Ming Yin

TL;DR: This assay utilizes a custom CRISPR Cas12a/gRNA complex and a fluorescent probe to amplify target amplicons produced by standard RT-PCR or isothermal recombinase polymerase amplification (RPA) to allow sensitive detection at sites not equipped with real-time PCR systems required for qPCR diagnostics.

TL;DR: An isolation-free smartphone-based saliva assay that can diagnose COVID-19 cases and quantify viral load within 15 min and exhibited a limit of detection below that of the RT-PCR reference assay is described.

TL;DR: In this article, the authors showed that SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis and increased pulmonary vascular permeability leading to edema and hemorrhage.

TL;DR: In this article, extracellular vesicles directly captured from plasma are fused with reagent-loaded liposomes to sensitively amplify and detect a SARS-CoV-2 gene target.

TL;DR: The results indicate that while at the population level the Ct value is lower, suggesting a higher viral load, in the symptomatic spreaders than that in the asymptomatic non-spreaders, there is significant overlap in the Ct values between the two groups, suggesting that a sensitive method is needed to identify asymPTomatic persons who may carry a low viral load but can still be infectious.