C
Christopher M. Walker
Researcher at Ohio State University
Publications - 106
Citations - 9861
Christopher M. Walker is an academic researcher from Ohio State University. The author has contributed to research in topics: Cytotoxic T cell & Epitope. The author has an hindex of 44, co-authored 97 publications receiving 9369 citations. Previous affiliations of Christopher M. Walker include Nationwide Children's Hospital & The Research Institute at Nationwide Children's Hospital.
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Journal ArticleDOI
Analysis of a successful immune response against hepatitis C virus
Stewart Cooper,Ann L. Erickson,Erin J. Adams,Joe Kansopon,Amy J. Weiner,David Y. Chien,Michael Houghton,Peter Parham,Christopher M. Walker +8 more
TL;DR: It is suggested that CD8+CTL are better correlated with protection against HCV infection than antibodies, and every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution.
Journal ArticleDOI
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
Arash Grakoui,Naglaa H. Shoukry,David John Woollard,Jin-Hwan Han,Holly L. Hanson,John Ghrayeb,Krishna K. Murthy,Charles M. Rice,Christopher M. Walker +8 more
TL;DR: Incomplete control of HCV replication by memory CD8+ Tcells in the absence of adequate CD4+ Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex–restricted epitopes and failure to resolve HCV infection.
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Adaptive immune responses in acute and chronic hepatitis C virus infection
TL;DR: Key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.
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Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
Naglaa H. Shoukry,Arash Grakoui,Michael Houghton,David Y. Chien,John Ghrayeb,Keith A. Reimann,Christopher M. Walker +6 more
TL;DR: An essential role for memory CD8+ T cells in long-term protection from chronic hepatitis C is demonstrated by antibody-mediated depletion of this lymphocyte subset before a third infection.
Journal ArticleDOI
Dystrophin Immunity in Duchenne's Muscular Dystrophy
Jerry R. Mendell,Katherine J. Campbell,Katherine J. Campbell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Zarife Sahenk,Zarife Sahenk,Chris Shilling,Sarah Lewis,Dawn E. Bowles,Steven J. Gray,Chengwen Li,Gloria Galloway,Vinod Malik,Brian D. Coley,K. Reed Clark,Juan Li,Xiao Xiao,Jade Samulski,Scott W. McPhee,R. Jude Samulski,Christopher M. Walker,Christopher M. Walker +22 more
TL;DR: The potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in designing and monitoring experimental therapies for Duchenne's muscular dystrophy.