V
Vinod Malik
Researcher at Nationwide Children's Hospital
Publications - 30
Citations - 2708
Vinod Malik is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Duchenne muscular dystrophy & Muscular dystrophy. The author has an hindex of 17, co-authored 24 publications receiving 2433 citations. Previous affiliations of Vinod Malik include Ohio State University & The Research Institute at Nationwide Children's Hospital.
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Journal ArticleDOI
Eteplirsen for the treatment of Duchenne muscular dystrophy
Jerry R. Mendell,Louise R. Rodino-Klapac,Zarife Sahenk,Kandice Roush,Loren Bird,Linda Lowes,Lindsay N. Alfano,Ann Maria Gomez,Sarah Lewis,Janaiah Kota,Vinod Malik,Kim Shontz,Christopher M. Walker,Kevin M. Flanigan,Marco Corridore,John R. Kean,Hugh D. Allen,Chris Shilling,Kathleen R. Melia,Peter Sazani,Jay B. Saoud,Edward M. Kaye +21 more
TL;DR: The authors used a double-blind placebo controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6-minute walk test (6MWT).
Journal ArticleDOI
Dystrophin Immunity in Duchenne's Muscular Dystrophy
Jerry R. Mendell,Katherine J. Campbell,Katherine J. Campbell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Zarife Sahenk,Zarife Sahenk,Chris Shilling,Sarah Lewis,Dawn E. Bowles,Steven J. Gray,Chengwen Li,Gloria Galloway,Vinod Malik,Brian D. Coley,K. Reed Clark,Juan Li,Xiao Xiao,Jade Samulski,Scott W. McPhee,R. Jude Samulski,Christopher M. Walker,Christopher M. Walker +22 more
TL;DR: The potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in designing and monitoring experimental therapies for Duchenne's muscular dystrophy.
Journal ArticleDOI
Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy.
Vinod Malik,Louise R. Rodino-Klapac,Laurence Viollet,Cheryl Wall,Wendy King,Roula al-Dahhak,Sarah Lewis,Christopher Shilling,Janaiah Kota,Carmen Serrano-Munuera,John R. Hayes,John D. Mahan,Katherine J. Campbell,Brenda Banwell,Majed Dasouki,Victoria Watts,Kumaraswamy Sivakumar,Ricardo Bien-Willner,Kevin M. Flanigan,Zarife Sahenk,Richard J. Barohn,Christopher M. Walker,Jerry R. Mendell +22 more
TL;DR: Mutation suppression of stop codons, successfully achieved in the mdx mouse using gentamicin, represents an important evolving treatment strategy in Duchenne muscular dystrophy (DMD).
Journal ArticleDOI
Sustained Alpha-Sarcoglycan Gene Expression after Gene Transfer in Limb- Girdle Muscular Dystrophy, Type 2D
Jerry R. Mendell,Jerry R. Mendell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Xiomara Q. Rosales,Brian D. Coley,Gloria Galloway,Gloria Galloway,Sarah Lewis,Vinod Malik,Chris Shilling,Barry J. Byrne,Thomas J. Conlon,Katherine J. Campbell,William G. Bremer,Laura E. Taylor,Kevin M. Flanigan,Kevin M. Flanigan,Julie M. Gastier-Foster,Caroline Astbury,Janaiah Kota,Zarife Sahenk,Zarife Sahenk,Christopher M. Walker,Christopher M. Walker,K. Reed Clark,K. Reed Clark +26 more
TL;DR: The aim of this study was to attain long‐lasting alpha‐sarcoglycan gene expression in limb‐girdle muscular dystrophy, type 2D subjects mediated by adeno‐associated virus (AAV) gene transfer under control of a muscle specific promoter (tMCK).
Journal ArticleDOI
A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy
Jerry R. Mendell,Jerry R. Mendell,Zarife Sahenk,Zarife Sahenk,Vinod Malik,A.M. Gomez,Kevin M. Flanigan,Kevin M. Flanigan,Linda Lowes,Lindsay N. Alfano,K. Berry,Eric Meadows,Sarah Lewis,Lyndsey Braun,Kim Shontz,Maria Rouhana,Kelly Reed Clark,Kelly Reed Clark,Xiomara Q. Rosales,Xiomara Q. Rosales,Samiah Al-Zaidy,Samiah Al-Zaidy,Alessandra Govoni,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Mark J. Hogan,Brian K. Kaspar,Brian K. Kaspar +27 more
TL;DR: Benefit showing reduced endomysial fibrosis, reduced central nucleation, more normal fiber size distribution with muscle hypertrophy, especially at high dose is encouraging for treatment of dystrophin-deficient muscle diseases.