S
Sarah Lewis
Researcher at Nationwide Children's Hospital
Publications - 27
Citations - 4047
Sarah Lewis is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Duchenne muscular dystrophy & Eteplirsen. The author has an hindex of 14, co-authored 26 publications receiving 3494 citations. Previous affiliations of Sarah Lewis include The Research Institute at Nationwide Children's Hospital & Ohio State University.
Papers
More filters
Journal ArticleDOI
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Laura L. Listenberger,Xianlin Han,Sarah Lewis,Sylvaine Cases,Robert V. Farese,Daniel S. Ory,Jean E. Schaffer +6 more
TL;DR: This work demonstrates in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates, and supports a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation.
Journal ArticleDOI
Dystrophin Immunity in Duchenne's Muscular Dystrophy
Jerry R. Mendell,Katherine J. Campbell,Katherine J. Campbell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Zarife Sahenk,Zarife Sahenk,Chris Shilling,Sarah Lewis,Dawn E. Bowles,Steven J. Gray,Chengwen Li,Gloria Galloway,Vinod Malik,Brian D. Coley,K. Reed Clark,Juan Li,Xiao Xiao,Jade Samulski,Scott W. McPhee,R. Jude Samulski,Christopher M. Walker,Christopher M. Walker +22 more
TL;DR: The potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in designing and monitoring experimental therapies for Duchenne's muscular dystrophy.
Journal Article
Eteplirsen for the Treatment of Duchenne Muscular Dystrophy (DMD) (S42.001)
Jay S. Charleston,F.J. Schnell,Johannes Dworzak,Cas Donoghue,J Lynch,Sarah Lewis,Lei Chen,Louise R. Rodino-Klapac,Zarife Sahenk,Jon Voss,U. DeAlwis,D. Frank,H Eliopoulos,J. Mendell +13 more
TL;DR: The present study used a double‐blind placebo‐controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6‐minute walk test.
Journal ArticleDOI
Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy.
Vinod Malik,Louise R. Rodino-Klapac,Laurence Viollet,Cheryl Wall,Wendy King,Roula al-Dahhak,Sarah Lewis,Christopher Shilling,Janaiah Kota,Carmen Serrano-Munuera,John R. Hayes,John D. Mahan,Katherine J. Campbell,Brenda Banwell,Majed Dasouki,Victoria Watts,Kumaraswamy Sivakumar,Ricardo Bien-Willner,Kevin M. Flanigan,Zarife Sahenk,Richard J. Barohn,Christopher M. Walker,Jerry R. Mendell +22 more
TL;DR: Mutation suppression of stop codons, successfully achieved in the mdx mouse using gentamicin, represents an important evolving treatment strategy in Duchenne muscular dystrophy (DMD).
Journal ArticleDOI
Sustained Alpha-Sarcoglycan Gene Expression after Gene Transfer in Limb- Girdle Muscular Dystrophy, Type 2D
Jerry R. Mendell,Jerry R. Mendell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Xiomara Q. Rosales,Brian D. Coley,Gloria Galloway,Gloria Galloway,Sarah Lewis,Vinod Malik,Chris Shilling,Barry J. Byrne,Thomas J. Conlon,Katherine J. Campbell,William G. Bremer,Laura E. Taylor,Kevin M. Flanigan,Kevin M. Flanigan,Julie M. Gastier-Foster,Caroline Astbury,Janaiah Kota,Zarife Sahenk,Zarife Sahenk,Christopher M. Walker,Christopher M. Walker,K. Reed Clark,K. Reed Clark +26 more
TL;DR: The aim of this study was to attain long‐lasting alpha‐sarcoglycan gene expression in limb‐girdle muscular dystrophy, type 2D subjects mediated by adeno‐associated virus (AAV) gene transfer under control of a muscle specific promoter (tMCK).