Z
Zarife Sahenk
Researcher at Nationwide Children's Hospital
Publications - 140
Citations - 10097
Zarife Sahenk is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Duchenne muscular dystrophy & Muscular dystrophy. The author has an hindex of 53, co-authored 132 publications receiving 9123 citations. Previous affiliations of Zarife Sahenk include Ohio State University & The Research Institute at Nationwide Children's Hospital.
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Journal ArticleDOI
Eteplirsen for the treatment of Duchenne muscular dystrophy
Jerry R. Mendell,Louise R. Rodino-Klapac,Zarife Sahenk,Kandice Roush,Loren Bird,Linda Lowes,Lindsay N. Alfano,Ann Maria Gomez,Sarah Lewis,Janaiah Kota,Vinod Malik,Kim Shontz,Christopher M. Walker,Kevin M. Flanigan,Marco Corridore,John R. Kean,Hugh D. Allen,Chris Shilling,Kathleen R. Melia,Peter Sazani,Jay B. Saoud,Edward M. Kaye +21 more
TL;DR: The authors used a double-blind placebo controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6-minute walk test (6MWT).
Journal ArticleDOI
Dystrophin Immunity in Duchenne's Muscular Dystrophy
Jerry R. Mendell,Katherine J. Campbell,Katherine J. Campbell,Louise R. Rodino-Klapac,Louise R. Rodino-Klapac,Zarife Sahenk,Zarife Sahenk,Chris Shilling,Sarah Lewis,Dawn E. Bowles,Steven J. Gray,Chengwen Li,Gloria Galloway,Vinod Malik,Brian D. Coley,K. Reed Clark,Juan Li,Xiao Xiao,Jade Samulski,Scott W. McPhee,R. Jude Samulski,Christopher M. Walker,Christopher M. Walker +22 more
TL;DR: The potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in designing and monitoring experimental therapies for Duchenne's muscular dystrophy.
Journal ArticleDOI
Myoblast Transfer in the Treatment of Duchenne's Muscular Dystrophy
Jerry R. Mendell,John T. Kissel,Anthony A. Amato,Wendy C. King,Linda Signore,Thomas W. Prior,Zarife Sahenk,Sandra Benson,Patricia E. McAndrew,Robert R. Rice,Haikady N. Nagaraja,Ralph E. Stephens,Laura E. Lantry,Glen E. Morris,Arthur H.M. Burghes +14 more
TL;DR: The value of exon-specific peptide antibodies in the interpretation of myoblast-transfer results was demonstrated in a patient with Duchenne's muscular dystrophy who had a high percentage of donor-derived dystrophin.
Journal ArticleDOI
Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
Swarnali Acharyya,S. Armando Villalta,Nadine Bakkar,Tepmanas Bupha-Intr,Paul M.L. Janssen,Micheal Carathers,Zhi-Wei Li,Amer A. Beg,Sankar Ghosh,Zarife Sahenk,Michael Weinstein,Katherine L. Gardner,Jill A. Rafael-Fortney,Michael Karin,James G. Tidball,Albert S. Baldwin,Denis C. Guttridge +16 more
TL;DR: It is suggested that the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD and specific pharmacological inhibition of IKK resulted in improved pathology and muscle function in mdx mice.
Journal Article
Eteplirsen for the Treatment of Duchenne Muscular Dystrophy (DMD) (S42.001)
Jay S. Charleston,F.J. Schnell,Johannes Dworzak,Cas Donoghue,J Lynch,Sarah Lewis,Lei Chen,Louise R. Rodino-Klapac,Zarife Sahenk,Jon Voss,U. DeAlwis,D. Frank,H Eliopoulos,J. Mendell +13 more
TL;DR: The present study used a double‐blind placebo‐controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6‐minute walk test.