D
Duncan MacGregor
Researcher at Royal Children's Hospital
Publications - 90
Citations - 5185
Duncan MacGregor is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Antigen & Cortical dysplasia. The author has an hindex of 34, co-authored 87 publications receiving 4774 citations. Previous affiliations of Duncan MacGregor include Austin Hospital & University of New South Wales.
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Journal ArticleDOI
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma
Mark J. Smyth,Kevin Y. T. Thia,Shayna E. A. Street,Duncan MacGregor,Dale I. Godfrey,Joseph A. Trapani +5 more
TL;DR: This study is the first that implicates direct cytotoxicity by lymphocytes in regulating lymphomagenesis, and shows that pfp-deficient mice have a high incidence of malignancy in distinct lymphoid cell lineages (T, B, NKT), indicating a specific requirement for pfp in protection against lymphmagenesis.
Journal ArticleDOI
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans.
Ian D. Davis,Weisan Chen,Heather Jackson,Phillip Parente,Phillip Parente,Mark Shackleton,Mark Shackleton,Mark Shackleton,Wendie Hopkins,Qiyuan Chen,Nektaria Dimopoulos,Tina Luke,Roger Murphy,Andrew M. Scott,Andrew M. Scott,Eugene Maraskovsky,Grant A. McArthur,Duncan MacGregor,Sue Sturrock,Tsin Yee Tai,Simon Green,Andrew Cuthbertson,Darryl W. Maher,Lena Miloradovic,Susan V. Mitchell,Gerd Ritter,Achim A. Jungbluth,Yao-Tseng Chen,Yao-Tseng Chen,Sacha Gnjatic,Eric W. Hoffman,Lloyd J. Old,Jonathan Cebon,Jonathan Cebon +33 more
TL;DR: In an unplanned analysis, vaccinated patients appeared to have superior clinical outcomes to those treated with placebo or protein alone, suggesting the vaccine is safe and highly potent immunologically.
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Suppression of lymphoma and epithelial malignancies effected by interferon gamma
TL;DR: Sp spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF) is described.
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A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors
Andrew M. Scott,Fook-Thean Lee,Niall C. Tebbutt,R. A. Herbertson,S Gill,Zhanqi Liu,Effie Skrinos,Carmel Murone,T. Saunder,Bridget Chappell,Anthony T. Papenfuss,A. M. T. Poon,Wendie Hopkins,Fiona E Smyth,Duncan MacGregor,Lawrence M Cher,Achim A. Jungbluth,Gerd Ritter,Martin W. Brechbiel,Roger Murphy,Antony W. Burgess,Eric W. Hoffman,Terrance Grant Johns,Lloyd J. Old +23 more
TL;DR: The present clinical study was designed to examine the in vivo specificity of a chimeric form of mAb 806 (ch806) in a tumor targeting/biodistribution/pharmacokinetic analysis in patients with diverse tumor types, and showed excellent targeting of tumor sites in all patients, no evidence of normal tissue uptake, and no significant toxicity.
Journal ArticleDOI
Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and γδ T Cells
Shayna E. A. Street,Yoshihiro Hayakawa,Yifan Zhan,Andrew M. Lew,Duncan MacGregor,Amanda M. Jamieson,Andreas Diefenbach,Hideo Yagita,Dale I. Godfrey,Mark J. Smyth +9 more
TL;DR: A critical role for NK cells and γδTCR+ T cells in innate immune surveillance of B cell lymphomas, mediated by as yet undetermined pathway(s) of tumor recognition is reflected.