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Chunru Lin
Researcher at University of California, San Diego
Publications - 7
Citations - 1828
Chunru Lin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Regulation of gene expression & Gene. The author has an hindex of 6, co-authored 7 publications receiving 1685 citations. Previous affiliations of Chunru Lin include University of Texas MD Anderson Cancer Center.
Papers
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Journal ArticleDOI
Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer
Chunru Lin,Liuqing Yang,Bogdan Tanasa,Bogdan Tanasa,Kasey R. Hutt,Bong-Gun Ju,Bong-Gun Ju,Kenneth A. Ohgi,Jie Zhang,David W. Rose,Xiang-Dong Fu,Christopher K. Glass,Michael G. Rosenfeld +12 more
TL;DR: The data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes.
Journal ArticleDOI
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
Liuqing Yang,Chunru Lin,Chunru Lin,Chunyu Jin,Joy C. Yang,Bogdan Tanasa,Bogdan Tanasa,Wenbo Li,Daria Merkurjev,Kenneth A. Ohgi,Da Meng,Jie Zhang,Christopher P. Evans,Michael G. Rosenfeld +13 more
TL;DR: Together, these results indicate that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumours.
Journal ArticleDOI
ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs
Liuqing Yang,Chunru Lin,Wen Liu,Jie Zhang,Kenneth A. Ohgi,Jonathan D. Grinstein,Pieter C. Dorrestein,Michael G. Rosenfeld +7 more
TL;DR: Observations delineate a molecular pathway linking the actions of subnuclear structure-specific ncRNAs and nonhistone protein methylation to relocation of transcription units in the three-dimensional space of the nucleus, thus achieving coordinated gene expression programs.
Journal ArticleDOI
Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.
Chunyu Jin,Liuqing Yang,Liuqing Yang,Min Xie,Chunru Lin,Chunru Lin,Daria Merkurjev,Joy C. Yang,Bogdan Tanasa,Soohwan Oh,Jie Zhang,Kenneth A. Ohgi,Hongyan Zhou,Wenbo Li,Christopher P. Evans,Sheng Ding,Michael G. Rosenfeld +16 more
TL;DR: It is demonstrated that SD70 inhibits the androgen-dependent AR program, and prostate cancer cell growth, acting, at least in part, by functionally inhibiting the Jumonji domain-containing demethylase, KDM4C.
Book ChapterDOI
Molecular Logic Underlying Chromosomal Translocations, Random or Non-Random?
TL;DR: This review will focus on the progression toward understanding the molecular logic underlying chromosome translocation events and implications of new strategies for preventing chromosomal translocations.