C
Cindy Luongo
Researcher at National Institutes of Health
Publications - 54
Citations - 5629
Cindy Luongo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Respiratory Syncytial Virus Vaccines. The author has an hindex of 30, co-authored 47 publications receiving 5298 citations. Previous affiliations of Cindy Luongo include University of Wisconsin-Madison.
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Journal ArticleDOI
Loss of activities for mRNA synthesis accompanies loss of lambda2 spikes from reovirus cores: an effect of lambda2 on lambda1 shell structure.
Cindy Luongo,Xing Zhang,Stephen B. Walker,Ya Chen,Teresa J. Broering,Teresa J. Broering,Diane L. Farsetta,Valorie D. Bowman,Timothy S. Baker,Max L. Nibert +9 more
TL;DR: Comparison of the core and spikeless core structures obtained by cryo-TEM and three-dimensional image reconstruction revealed changes in the lambda1 core shell that accompany lambda2 loss, most notably the elimination of small pores that span the shell near the icosahedral fivefold axes.
Journal ArticleDOI
Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity.
Cyril Le Nouën,Cindy Luongo,Lijuan Yang,Steffen Mueller,Eckard Wimmer,Joshua M. DiNapoli,Peter L. Collins,Ursula J. Buchholz +7 more
TL;DR: Paradigms of CPO of an RNA virus for a mammalian host has paradoxical effects on virus replication and the adaptive humoral immune response.
Journal ArticleDOI
α-Fetoprotein Gene Delivery to the Nasal Epithelium of Nonhuman Primates by Human Parainfluenza Viral Vectors
Liqun Zhang,Maria P. Limberis,Catherine Thompson,Marcelo B. Antunes,Cindy Luongo,James M. Wilson,Peter L. Collins,Raymond J. Pickles +7 more
TL;DR: It is demonstrated that PIV mediates efficient gene transfer in rhesus epithelium as in the human counterpart, and PIV vectors appear to be promising airway-specific gene transfer vehicles that warrant further development.
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Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys
Cyril Le Nouën,Christine E. Nelson,Xueqiao Liu,Hong-Su Park,Yumiko Matsuoka,Cindy Luongo,Celia Santos,Lijuan Yang,Richard Herbert,Ashley Castens,Ian N. Moore,Temeri Wilder-Kofie,Rashida Moore,A. Walker,Feng Zhang,Paolo Lusso,Reed F. Johnson,Nicole L. Garza,Laura E. Via,Shirin Munir,Daniel L. Barber,Ursula J. Buchholz +21 more
TL;DR: In this article , a live-attenuated parainfluenza-virus-vectored vaccine candidate expressing SARS-CoV-2 prefusion-stabilized spike (S) protein (B/HPIV3/S-6P) was evaluated in rhesus macaques.
Journal ArticleDOI
Evaluation of Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccines RSV/ΔNS2/Δ1313/I1314L and RSV/276 in RSV Seronegative Children.
Coleen K. Cunningham,Ruth A. Karron,Petronella Muresan,Matthew S. Kelly,Elizabeth J. McFarland,Charlotte Perlowski,Jennifer Libous,Jennifer Oliva,Patrick Jean-Philippe,Jack Moye,Elizabeth Schappell,Emily Barr,Vivian Rexroad,B. L. Johnston,M. Chadwick,Mikhaela Cielo,Mary Rearick Paul,Jaime G. Deville,Maria Aziz,Lijuan Yang,Cindy Luongo,Peter L. Collins,Ursula J. Buchholz +22 more
TL;DR: Both vaccines had excellent infectivity and were well-tolerated and primed for strong anamnestic RSV-antibody responses.