M
Maria P. Limberis
Researcher at University of Pennsylvania
Publications - 64
Citations - 2244
Maria P. Limberis is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cystic fibrosis & Genetic enhancement. The author has an hindex of 24, co-authored 60 publications receiving 1973 citations. Previous affiliations of Maria P. Limberis include Boston Children's Hospital & Wistar Institute.
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Journal ArticleDOI
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial
Eric W.F.W. Alton,David K Armstrong,Deborah Ashby,Katie J Bayfield,Diana Bilton,Emily V Bloomfield,A. Christopher Boyd,June Brand,Ruaridh Buchan,Roberto Calcedo,Paula Carvelli,Mario Chan,Seng H. Cheng,David Collie,Steve Cunningham,Heather E Davidson,Gwyneth Davies,Jane C. Davies,Lee A. Davies,Maria H Dewar,Ann Doherty,Jackie Donovan,Natalie S Dwyer,Hala I Elgmati,Rosanna F Featherstone,Jemyr Gavino,Sabrina Gea-Sorli,Duncan M. Geddes,James Sr Gibson,Deborah R. Gill,Andrew P. Greening,Uta Griesenbach,David M. Hansell,Katharine Harman,T Higgins,Samantha L Hodges,Stephen C. Hyde,Laura Hyndman,J. Alastair Innes,Joseph Jacob,Nancy Aaron Jones,Brian F Keogh,Maria P. Limberis,Paul Lloyd-Evans,Alan W Maclean,Michelle C Manvell,Dominique McCormick,Michael McGovern,Gerry McLachlan,C Meng,M Angeles Montero,Hazel Milligan,Laura J Moyce,Gordon D Murray,Andrew G. Nicholson,Tina Osadolor,Javier Parra-Leiton,David J. Porteous,Ian A. Pringle,Emma K Punch,Kamila M Pytel,Alexandra L. Quittner,Gina Rivellini,Clare Saunders,Ronald K. Scheule,Sarah Sheard,Nicholas J. Simmonds,Keith Smith,Stephen N. Smith,Najwa Soussi,Samia Soussi,Emma J Spearing,Barbara J Stevenson,Stephanie G Sumner-Jones,Minna Turkkila,Rosa P Ureta,Michael D Waller,Marguerite Y Wasowicz,James M. Wilson,Paul Wolstenholme-Hogg +79 more
TL;DR: In this article, a randomized, double-blind, placebo-controlled, phase 2b trial was conducted to assess the efficacy of non-viral CFTR gene therapy in patients with cystic fibrosis, where patients were randomly assigned to receive 5 mL of either nebulised pGM169/GL67A gene-liposome complex or 0·9% saline (placebo) every 28 days for 1 year.
Journal ArticleDOI
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
Christie L. Bell,Luk H. Vandenberghe,Peter Bell,Maria P. Limberis,Guangping Gao,Kim Van Vliet,Mavis Agbandje-McKenna,James M. Wilson +7 more
TL;DR: Co-instillation of AAV9 vector with neuraminidase into mouse lung resulted in exposure of terminal galactose on the apical surface of conducting airway epithelial cells, as shown by lectin binding and increased transduction of these cells, demonstrating the possible utility of this vector in lung-directed gene transfer.
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Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro.
TL;DR: It is demonstrated that AAV6.2 exhibits improved transduction efficiency compared to previously reported AAVs in mouse airways and in culture models of human airway epithelium and that this vector requires further development for preclinical and clinical testing.
Journal ArticleDOI
Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered.
TL;DR: It is shown that AAV2/9 can be readministered in the presence of high levels of serum-circulating neutralizing antibodies as early as 1 month after initial exposure, with minimal effect on overall reporter gene expression, rendering it a promising gene transfer vector candidate for use in humans.
Journal ArticleDOI
Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Nick S. Laursen,Robert H. E. Friesen,Xueyong Zhu,Mandy Jongeneelen,Sven Blokland,Jan Vermond,A. van Eijgen,Chan Tang,H. van Diepen,G. Obmolova,M. van der Neut Kolfschoten,David Zuijdgeest,R. Straetemans,Ryan M. B. Hoffman,Travis Nieusma,Jesper Pallesen,Hannah L. Turner,Steffen M. Bernard,Andrew B. Ward,J. Luo,Leo L.M. Poon,Anna Tretiakova,James M. Wilson,Maria P. Limberis,Ronald Vogels,Boerries Brandenburg,J.A. Kolkman,Ian A. Wilson +27 more
TL;DR: These findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency, and may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.