Showing papers by "Claire N. Harrison published in 2010"
TL;DR: Results indicate that different pathogenetic mechanisms underlie transformation to JAK2 wild-type and JAK1-mutant AML, show that TET2 mutations may be present in a clone distinct from that harboring aJAK2 mutation, and emphasize the clonal heterogeneity of the MPNs.
271 citations
TL;DR: This map shows the main referral routes for new admissions to the Royal Infirmary, Gartnavel General Hospital, Glasgow, and Belfast City Hospital.
Abstract: Guy’s and St Thomas’ NHS Foundation Trust, London, Russells Hall Hospital, Dudley, West Midlands, Arrowe Park Hospital Arrowe Park Road Upton Wirral, Wellcome Trust Sanger Institute, Hinxton, Cambridge, St. James Hospital, James Street, Dublin, Gartnavel General Hospital 21 Shelley Road Glasgow, Addenbrooke’s Hospital, Cambridge, Salisbury Healthcare NHS Trust, Salisbury, Wiltshire, Cambridge Institute for Medical Research, Hills Road, Cambridge, John Radcliffe Hospital, Headley Way, Headington, Oxford, Royal Infirmary, Little France Crescent, Edinburgh, Sandwell and West Birmingham Hospitals, Dudley Road, Birmingham, Royal Hallamshire Hospital, Glossop Road, Sheffield, and Belfast City Hospital, Lisburn Road Belfast, UK
261 citations
TL;DR: A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis : results of a European LeukemiaNet (ELN) consensus process are published.
Abstract: A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis : results of a European LeukemiaNet (ELN) consensus process
140 citations
TL;DR: The excess of 46/1 in JAK2 exon 12 cases is compatible with both the "hypermutability" and "fertile ground" hypotheses, but the excess in MPL-mutated cases argues against the former.
98 citations
01 Jan 2010
TL;DR: It is called for researchers, educators, policy makers and practitioners alike to re-imagine the role and purpose of social science enquiry that could enable the delivery of more socially engaged nutrition sciences.
28 citations
TL;DR: This article reviews four major themes: the impact upon classification of these disorders considering a radical review of current terminology, the indications for cytoreductive therapy in which the key targets are to reduce thrombohemorrhagic complications, relieve disease-related symptoms, and minimize the risk of transformation to secondary myeloid malignancy, and current and future therapeutic options.
Abstract: The seminal discovery of the JAK2V617F mutation, which is highly prevalent in Philadelphia-negative myeloproliferative disorders, now renamed neoplasms, triggered an almost unprecedented explosion of interest and data in the field. Descriptions of additional mutations in exon 12 of JAK2, at position 515 in MPL, and a number of other mutations at low frequency followed these discoveries. These advances in our understanding of molecular pathogenesis of these conditions coincided with the publication of results from two major clinical studies, ECLAP and PT-1, which contributed important clinical insights and facilitated significant correlative data collection. This article, focusing mainly upon essential thrombocythemia and polycythemia vera, reviews four major themes: the impact upon classification of these disorders considering a radical review of current terminology, and then three areas pertinent to clinical management: the indications for cytoreductive therapy in which the key targets are to reduce thrombohemorrhagic complications, relieve disease-related symptoms, and minimize the risk of transformation to secondary myeloid malignancy such as myelodysplasia, leukemia, and secondary myelofibrosis; and second reviewing current and, last, future therapeutic options, in particular interferon and JAK2 inhibitors.
22 citations
TL;DR: Since the inception of blood banking, refinements in laboratory processes have allowed for progressively longer storage times of red blood cells, which are advantageous for the logistics of stock management and a topic of growing interest.
Abstract: Since the inception of blood banking, refinements in laboratory processes have allowed for progressively longer storage times of red blood cells. Whilst advantageous for the logistics of stock management, the clinical impact of the duration of red blood cell storage prior to transfusion remains uncertain, and a topic of growing interest.
14 citations
TL;DR: A 66-year-old man with polycythaemia vera develops splenomegaly with marked abdominal discomfort after a single 1 Gy fraction of splenic irradiation and develops TLS and ARF, an oncological emergency usually caused by lysis of tumour cells resulting in rapid release of potassium, purine nucleic acids and phosphorus.
5 citations
TL;DR: The MPN-SAF is recommended as a uniform symptom assessment tool for MPN patients participating in clinical trials globally and is comprehensive and reliable instrument which is available in multiple languages to evaluate MPn-associated symptoms.
1 citations
TL;DR: A morphology session is held each year at the Annual Scientific Meeting of the British Society of Haematology, where eight morphology cases were made available to BSH members as glass slides and also digitally as ‘virtual slides’.
Abstract: Summary
A morphology session is held each year at the Annual Scientific Meeting of the British Society of Haematology. Prior to the meeting this year, eight morphology cases were made available to BSH members as glass slides and also digitally as ‘virtual slides’. A panel of invited commentators who had no prior knowledge of the diagnosis discussed the eight cases. An initial limited history and blood count are given with representative images from the case material; this is followed by the discussants’ comments and suggested diagnosis. The actual clinical diagnosis is then given with other relevant information.