C
Clare Bao
Researcher at Johns Hopkins University School of Medicine
Publications - 24
Citations - 4900
Clare Bao is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 21, co-authored 24 publications receiving 4695 citations. Previous affiliations of Clare Bao include Johns Hopkins University.
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Journal ArticleDOI
Leptin regulates proinflammatory immune responses
S. Loffreda,Shu Yang,Huizhi Lin,Christopher L. Karp,ML Brengman,Dajie Wang,Andrew S. Klein,Gregory B. Bulkley,Clare Bao,Paul W. Noble,M D Lane,Anna Mae Diehl +11 more
TL;DR: An important and novel function for leptin is identified: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity.
Journal ArticleDOI
Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.
Charlotte M. McKee,Margaret B. Penno,Mary K. Cowman,Marie D. Burdick,Robert M. Strieter,Clare Bao,Paul W. Noble +6 more
TL;DR: The hypothesis that HA fragments generated during inflammation induce the expression of macrophage genes which are important in the development and maintenance of the inflammatory response is supported.
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Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
Kenji Matsushita,Craig N. Morrell,Béatrice Cambien,Shui Xiang Yang,Munekazu Yamakuchi,Clare Bao,Makoto R. Hara,Richard A. Quick,Wangsen Cao,Brian O'Rourke,John M. Lowenstein,Jonathan Pevsner,Denisa D. Wagner,Charles J. Lowenstein +13 more
TL;DR: It is shown that NO inhibits exocytosis of Weibel-Palade bodies, endothelial granules that mediate vascular inflammation and thrombosis, by regulating the activity of N-ethylmaleimide-sensitive factor (NSF).
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P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
Munekazu Yamakuchi,Craig Lotterman,Clare Bao,Ralph H. Hruban,Baktiar O. Karim,Joshua T. Mendell,David L. Huso,Charles J. Lowenstein +7 more
TL;DR: It is shown that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107, a microRNA expressed by human colon cancer specimens and regulated by p53, and that miR-107 can mediate p53 regulation of Hypoxic signaling and tumor angiogenesis.
Journal ArticleDOI
Hyaluronan Fragments Induce Nitric-oxide Synthase in Murine Macrophages through a Nuclear Factor κB-dependent Mechanism *
Charlotte M. McKee,Charles J. Lowenstein,Maureen R. Horton,Jean Wu,Clare Bao,Beek Yoke Chin,Augustine M.K. Choi,Paul W. Noble +7 more
TL;DR: Examination of the effect of low molecular weight fragments of the extracellular matrix glycosaminoglycan hyaluronan (HA) on the induction of nitric-oxide synthase (iNOS) in macrophages supports the hypothesis that HA may be an important regulator of macrophage activation at sites of chronic tissue inflammation.