Mimoza Hoti

TL;DR: It is shown that copy number variants (CNVs) show a variety of genetic signals consistent with rapid turnover and make substantial contributions to quantitative traits, most notably intracellular amino acid concentrations, growth under stress and sugar utilization in winemaking, whereas rearrangements are strongly associated with reproductive isolation.

TL;DR: Bolus-dose vitamin D3 supplementation did not influence time to exacerbation or URI in a population of adults with asthma with a high prevalence of baseline vitamin D insufficiency.

TL;DR: The hyperacute postinjury time window contained a focused, specific signature of the response to critical injury that led to widespread genomic activation, and showed enrichment among diseases and biological functions associated with cell survival and organismal death rather than inflammatory pathways.

TL;DR: It is indicated that multiple rare and common W NK1 variants contribute to BP variation and hypertension, and provide compelling evidence to initiate further genetic and functional studies to explore the role of WNK1 in BP regulation and EH.

TL;DR: Applying this optimized CRISPR/Cas9-based approach, this work has successfully deleted over 80 different non-coding RNA genes, which are generally lowly expressed, and have inserted 7 point mutations in 4 different genomic regions.