Clarence S.M. Chan

TL;DR: It is demonstrated that the Aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies, which implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy.

TL;DR: Systematic mutational analysis of the Ipl1p phosphorylation sites demonstrated that the essential microtubule binding protein Dam1p is a key IPl1p target for regulating kinetochore-microtubule attachments in vivo.

TL;DR: A rapid peptide screening approach was used to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Saccharomyces cerevisiae, and previously unappreciated rules for determining specificity within the kinase family were uncovered.

TL;DR: Experiments with a dominant positive PKC1 gene showed that the two effects of Rho1p are independent of each other, and the colocalization of R Ho1p with actin patches at the site of bud emergence and the role of R ho1p in cell wall synthesis emphasize the importance of RHo1pIn polarized growth and morphogenesis.

TL;DR: A network of interactions that provide an integrated response of signaling proteins, the cytoskeleton, and organelles to the spatial cues that direct polarity development was revealed.