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Claude N. Holenstein
Researcher at University of Zurich
Publications - 16
Citations - 258
Claude N. Holenstein is an academic researcher from University of Zurich. The author has contributed to research in topics: Traction force microscopy & Point cloud. The author has an hindex of 7, co-authored 15 publications receiving 178 citations. Previous affiliations of Claude N. Holenstein include Commonwealth Scientific and Industrial Research Organisation & ETH Zurich.
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Journal ArticleDOI
Biomaterial surface energy-driven ligand assembly strongly regulates stem cell mechanosensitivity and fate on very soft substrates
Tojo Razafiarison,Claude N. Holenstein,Claude N. Holenstein,Tino Stauber,Tino Stauber,Milan Jovic,Milan Jovic,Edward Vertudes,Edward Vertudes,Marko Loparic,Maciej Kawecki,Laetitia Bernard,Unai Silvan,Unai Silvan,Jess G. Snedeker +14 more
TL;DR: It is revealed that surface energy-driven supramolecular ligand assembly can regulate mesenchymal stem cell (MSC) sensing of substrate mechanical compliance and subsequent cell fate, filling a critical gap in basic understanding of cell–biomaterial interaction.
Journal ArticleDOI
High-resolution traction force microscopy on small focal adhesions - improved accuracy through optimal marker distribution and optical flow tracking
TL;DR: This work has developed a simulation platform for generating synthetic traction images that can be used as a benchmark to quantify the influence of critical experimental parameters and the associated errors, and provides the best available benchmark to date for defining practical limits to TFM accuracy as a function of focal adhesion size.
Journal ArticleDOI
The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells.
Claude N. Holenstein,Aron N. Horvath,Aron N. Horvath,Barbara Schär,Barbara Schär,Angelina D. Schoenenberger,Angelina D. Schoenenberger,Maja Bollhalder,Maja Bollhalder,Nils Goedecke,Guido Bartalena,Oliver Otto,Maik Herbig,Jochen Guck,Daniel Müller,Jess G. Snedeker,Jess G. Snedeker,Unai Silvan,Unai Silvan +18 more
TL;DR: The results reveal that the low metastatic osteosarcoma cells display larger spreading sizes and generate higher forces than the experimentally selected, highly malignant variants, indicating that only a set of phenotyping methods provides the full picture of cell mechanics.
Proceedings ArticleDOI
Watertight surface reconstruction of caves from 3D laser data
TL;DR: This work used a mobile lidar to map several kilometers of a natural cave system in order to obtain 3D volumetric models for use in scientific research studying the local palaeo-climatic record.
Journal ArticleDOI
Tendon response to matrix unloading is determined by the patho-physiological niche.
Stefania L. Wunderli,Ulrich Blache,Agnese Beretta Piccoli,Barbara Niederöst,Claude N. Holenstein,Fabian S. Passini,Unai Silvan,Louise Bundgaard,Ulrich auf dem Keller,Jess G. Snedeker,Jess G. Snedeker +10 more
TL;DR: It is concluded that the tendon stromal compartment responds to aberrant mechanical unloading in a manner that is highly dependent on the vascular niche, with ROS gating a complex proteolytic breakdown of the functional collagen backbone.