Claudio Cerchione

TL;DR: This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus on their dual role as tumor suppressors in nonmalignant cells and pseudo-oncogenes in cancer cells.

TL;DR: This paper describes the establishment and current content of the ImmuneCODE™ database, which includes hundreds of millions of T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with the SARS-CoV-2 virus, as well as over 135,000 high-confidence Sars-Cov-2-specific TCRs.

TL;DR: The principles that have guided the engineering of CAR-T cells and the specific prostatic antigens identified as possible targets for immunological and non-immunological therapies are reviewed and a state-of-the-art overview ofCAR-T cell therapy in PCa is provided.

TL;DR: The role of the immune system in acute myeloid leukemia (AML) development, growth and recurrence has gained increasing interest in the past few years and a better understanding of immunological escape and systemic tolerance induced by AML blasts has been achieved.

TL;DR: In this paper, the authors evaluated the effectiveness of CAR-T therapy in relapsed and refractory (R/R) B acute lymphoblastic leukemia (B-ALL) patients.