Claudio Collinet

TL;DR: A new strategy to phenotypically profile the human genome with respect to transferrin (TF) and epidermal growth factor (EGF) endocytosis is developed by combining RNA interference, automated high-resolution confocal microscopy, quantitative multiparametric image analysis and high-performance computing.

TL;DR: It is proposed that partitioning of Akt and selected effectors onto endosomal compartments represents a key mechanism contributing to the specificity of signal transduction in vertebrate development.

TL;DR: It is reported that tissue convergence and extension correlate mostly with new junction growth and it is found that tissue-scale pulling forces at the boundary with the invaginating posterior midgut actively participate in tissue extension by orienting junction growth.

TL;DR: It is proposed that, by reconciling module performance with progression of activity, the cut‐out switch design could underlie the integration of modules in regulatory cascades from a broad range of biological processes.

TL;DR: Analyzing the dynamics of junction shortening and elongation resulting from myosin II pulses, it is found that long pulses yield less reversible deformations, typically a signature of dissipative mechanics.