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Clement Mapanje
Researcher at University of North Carolina at Chapel Hill
Publications - Â 21
Citations - Â 1430
Clement Mapanje is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Acquired immunodeficiency syndrome (AIDS) & Cervical cancer. The author has an hindex of 10, co-authored 19 publications receiving 1320 citations. Previous affiliations of Clement Mapanje include Kamuzu Central Hospital.
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Journal ArticleDOI
Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants
Melissa-Rose Abrahams,Jeffrey A. Anderson,Elena E. Giorgi,Elena E. Giorgi,Cathal Seoighe,Koleka Mlisana,Li-Hua Ping,Gayathri Athreya,Florette K. Treurnicht,Brandon F. Keele,Natasha T. Wood,Jesus F. Salazar-Gonzalez,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Haitao Chu,Irving F. Hoffman,Shannon Galvin,Clement Mapanje,Peter N. Kazembe,Ruwayhida Thebus,Susan A. Fiscus,Winston Hide,Myron S. Cohen,S. S. Abdool Karim,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Bette T. Korber,Bette T. Korber,Ronald Swanstrom,Carolyn Williamson +30 more
TL;DR: In a combined analysis of 171 subtype B and C transmission events, it is found that infection with more than one variant does not follow a Poisson distribution, indicating that transmission of individual virions cannot be seen as independent events, each occurring with low probability.
Journal ArticleDOI
Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection.
Christopher D. Pilcher,George Joaki,Irving F. Hoffman,Francis Martinson,Clement Mapanje,Paul W. Stewart,Kimberly A. Powers,Shannon Galvin,David Chilongozi,Syze Gama,Matthew Price,Susan A. Fiscus,Myron S. Cohen +12 more
TL;DR: These results provide a biological explanation for reported increases in HIV transmission during the very early (acute) and late stages of infection.
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HIV partner notification is effective and feasible in sub-Saharan Africa: opportunities for HIV treatment and prevention.
Lillian B. Brown,William C. Miller,Gift Kamanga,Naomi Nyirenda,Pearson Mmodzi,Audrey Pettifor,Rosalie Dominik,Jay S. Kaufman,Jay S. Kaufman,Clement Mapanje,Francis Martinson,Myron S. Cohen,Irving F. Hoffman +12 more
TL;DR: This study provides the first evidence of the effectiveness of partner notification in sub-Saharan Africa and shows active partner notification was feasible, acceptable, and effective among sexually transmitted infections clinic patients.
Journal ArticleDOI
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants (Journal of Virology (2009) 83, 8, (3556-3567))
Melissa-Rose Abrahams,Jeffrey A. Anderson,Elena E. Giorgi,Cathal Seoighe,Koleka Mlisana,Li-Hua Ping,Gayathri Athreya,Florette K. Treurnicht,Brandon F. Keele,Natasha T. Wood,Jesus F. Salazar-Gonzalez,Tanmoy Bhattacharya,Haitao Chu,Irving F. Hoffman,Shannon Galvin,Clement Mapanje,Peter N. Kazembe,Ruwayhida Thebus,Susan A. Fiscus,Winston Hide,Myron S. Cohen,S. S. Abdool Karim,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Bette T. Korber,R. Swanstrom,Carolyn Williamson +27 more
Journal ArticleDOI
Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design
Li Hua Ping,Sarah B. Joseph,Jeffrey A. Anderson,Jeffrey A. Anderson,Melissa-Rose Abrahams,Jesus F. Salazar-Gonzalez,Laura P. Kincer,Florette K. Treurnicht,Leslie Arney,Suany Ojeda,Ming Zhang,Ming Zhang,Jessica Keys,E. Lake Potter,Haitao Chu,Penny L. Moore,Maria G. Salazar,Shilpa S. Iyer,Cassandra B. Jabara,Jennifer L. Kirchherr,Clement Mapanje,Nobubelo Ngandu,Cathal Seoighe,Irving F. Hoffman,Feng Gao,Yuyang Tang,Yuyang Tang,Celia C. LaBranche,Benhur Lee,Andrew Saville,Marion Vermeulen,Susan A. Fiscus,Lynn Morris,Salim S. Abdool Karim,Barton F. Haynes,George M. Shaw,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,Myron S. Cohen,David C. Montefiori,Carolyn Williamson,Ronald Swanstrom +42 more
TL;DR: It is suggested that the occasional absence of glycosylation sites encoded in the conserved regions of env, further reduced in transmitted viruses, could expose specific surface structures on the protein as antibody targets.