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Cliff Y Yang
Researcher at University of California, San Diego
Publications - 8
Citations - 1916
Cliff Y Yang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Population & Cellular differentiation. The author has an hindex of 6, co-authored 7 publications receiving 1694 citations.
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Journal ArticleDOI
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more
TL;DR: A critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus is demonstrated.
Journal ArticleDOI
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Cliff Y Yang,J Adam Best,Jamie Knell,Edward Yang,Alison D. Sheridan,Adam K Jesionek,Haiyan S. Li,Richard Rivera,Kristin Camfield Lind,Louise M. D’Cruz,Stephanie S. Watowich,Cornelis Murre,Ananda W. Goldrath +12 more
TL;DR: Deficiency in Id2 or Id3 resulted in loss of distinct CD8+ effector and memory populations, which demonstrated unique roles for these inhibitors of E-protein transcription factors and altered the expression of Id2 and Id3 differently, which provides insight into how external cues influence gene expression.
Journal ArticleDOI
Innate lymphoid cells promote lung tissue homeostasis following acute influenza virus infection
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more
TL;DR: A critical role is demonstrated for lung ILCs in restoring airway epithelial integrity and tissue homeostasis following influenza virus infection in mice and humans.
Journal ArticleDOI
The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development.
Haiyan S. Li,Cliff Y Yang,Kalyan C. Nallaparaju,Kalyan C. Nallaparaju,Huiyuan Zhang,Yong-Jun Liu,Yong-Jun Liu,Ananda W. Goldrath,Stephanie S. Watowich,Stephanie S. Watowich +9 more
TL;DR: The finding that STAT5 is required for tissue CD103(+) DC generation and plasmacytoid DC (pDC) suppression in steady state or response to GM-CSF suggests that STATs contribute to DC development by controlling transcription factors involved in lineage differentiation.
Journal ArticleDOI
E and Id Proteins Influence Invariant NKT Cell Sublineage Differentiation and Proliferation
TL;DR: Insight is provided into E and Id protein regulation of iNKT cell proliferation and differentiation to specific sublineages during development in the thymus, which is known to be influenced by defined subsets of invariant NKT cells residing in distinct locations within peripheral tissue.