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Brian J. Laidlaw
Researcher at University of California, San Francisco
Publications - 31
Citations - 4285
Brian J. Laidlaw is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 21, co-authored 28 publications receiving 3382 citations. Previous affiliations of Brian J. Laidlaw include Wistar Institute & Yale University.
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Journal ArticleDOI
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Laurel A. Monticelli,Gregory F. Sonnenberg,Michael C. Abt,Theresa Alenghat,Carly G. K. Ziegler,Travis A. Doering,Jill M. Angelosanto,Brian J. Laidlaw,Cliff Y Yang,Taheri Sathaliyawala,Masaru Kubota,Damian Turner,Joshua M. Diamond,Ananda W. Goldrath,Donna L. Farber,Ronald G. Collman,E. John Wherry,David Artis +17 more
TL;DR: A critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus is demonstrated.
Journal ArticleDOI
The multifaceted role of CD4 + T cells in CD8 + T cell memory
TL;DR: Recent studies are discussed that provide insight into the multifaceted role of CD4+ T cells in the regulation of memory CD8+ T cell differentiation.
Journal ArticleDOI
CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection
Brian J. Laidlaw,Nianzhi Zhang,Heather D. Marshall,Mathew M. Staron,Tianxia Guan,Yinghong Hu,Linda S. Cauley,Joe Craft,Susan M. Kaech,Susan M. Kaech +9 more
TL;DR: CD4(+) T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103(+) CD8(+) Trm cells in the lung airways following respiratory infection.
Journal ArticleDOI
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Yosuke Kumamoto,Melissa M. Linehan,Jason S. Weinstein,Brian J. Laidlaw,Joe Craft,Akiko Iwasaki +5 more
TL;DR: CD301b⁺ DDCs are revealed as the key mediators of Th2 immunity and led to blunted interleukin-4 production by OVA-specific OT-II transgenic CD4⁺ T cells and significantly impaired Th2 cell development upon infection with Nippostrongylus brasiliensis.
Journal ArticleDOI
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells
John P. Ray,Matthew M. Staron,Justin A. Shyer,Ping-Chih Ho,Heather D. Marshall,Simon M. Gray,Brian J. Laidlaw,Koichi Araki,Rafi Ahmed,Susan M. Kaech,Susan M. Kaech,Joe Craft +11 more
TL;DR: The interleukin-2 (IL-2)-mTORc1 axis is identified as a critical orchestrator of the reciprocal balance between Tfh and Th1 cell fates and their respective metabolic activities after acute viral infection.