N
Naohisa Oda
Researcher at Fujita Health University
Publications - 50
Citations - 5054
Naohisa Oda is an academic researcher from Fujita Health University. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 23, co-authored 50 publications receiving 4894 citations. Previous affiliations of Naohisa Oda include Nagoya University & University of Chicago.
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Journal ArticleDOI
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
Kazuya Yamagata,Hiroto Furuta,Naohisa Oda,Pamela J. Kaisaki,Stephan Menzel,Nancy J. Cox,Stefan S. Fajans,Stefano Signorini,Markus Stoffel,Graeme I. Bell +9 more
TL;DR: It is shown that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1α (HNF-1 α), which is encoded by the gene TCF1, which is a transcription factor that helps in the tissue-specific regulation of the expression of several liver genes.
Journal ArticleDOI
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Yukio Horikawa,Naohisa Oda,Nancy J. Cox,Xiuping Li,Xiuping Li,Marju Orho-Melander,Manami Hara,Yoshinori Hinokio,Yoshinori Hinokio,Tom H. Lindner,Hirosato Mashima,Peter Eh Schwarz,Peter Eh Schwarz,L. del Bosque-Plata,L. del Bosque-Plata,Y. Oda,Issei Yoshiuchi,Susan Colilla,Kenneth S. Polonsky,S Wei,Patrick Concannon,Naoko Iwasaki,Jan Schulze,Leslie J. Baier,Clifton Bogardus,Leif Groop,Eric Boerwinkle,Craig L. Hanis,Graeme I. Bell +28 more
TL;DR: The positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland is described, suggesting a novel pathway that may contribute to the development of type 1 diabetes.
Journal ArticleDOI
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
Leslie J. Baier,Paskasari A. Permana,Xiaolin Yang,Richard E. Pratley,Robert L. Hanson,Gong-Qing Shen,David D. Mott,William C. Knowler,Nancy J. Cox,Yukio Horikawa,Naohisa Oda,Graeme I. Bell,Clifton Bogardus +12 more
TL;DR: Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreases rates of glucose oxidation.
Journal ArticleDOI
The ratio of leptin to adiponectin can be used as an index of insulin resistance
Naohisa Oda,Shigeo Imamura,Takashi Fujita,Yuka Uchida,Kazumichi Inagaki,Hiroaki Kakizawa,Nobuki Hayakawa,Atsushi Suzuki,Jun Takeda,Yukio Horikawa,Mitsuyasu Itoh +10 more
TL;DR: The results indicate pioglitazone to be effective for HbA(1c) improvement in subjects with high L/A and low L-A, and metformin to beeffective for HBA( 1c) improved inSubjects with a lowL/A, as well as male and female subjects, to be different between male andFemale subjects.
Journal ArticleDOI
Identification of Nine Novel Mutations in the Hepatocyte Nuclear Factor 1 Alpha Gene Associated with Maturity-Onset Diabetes of the Young (MODY3)
Martine Vaxillaire,Martine Vaxillaire,Mathias Rouard,Kazuya Yamagata,Kazuya Yamagata,Naohisa Oda,Pamela J. Kaisaki,Pamela J. Kaisaki,V. Vicky Boriraj,Jean Claude Chevre,Valérie Boccio,Roger D. Cox,G. Mark Lathrop,P Dussoix,Jacques Philippe,José Timsit,Guillaume Charpentier,Gilberto Velho,Graeme I. Bell,Graeme I. Bell,Philippe Froguel +20 more
TL;DR: The mechanisms by which mutations in the HNF-1alpha gene cause diabetes mellitus are unclear but might include abnormal pancreatic islet development during foetal life thereby limiting their later function, as well as impaired transcriptional regulation of genes that play a key role in normal pancreatic beta cell function.