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Colin Macaulay
Researcher at University of Alberta
Publications - 22
Citations - 867
Colin Macaulay is an academic researcher from University of Alberta. The author has contributed to research in topics: Serpin & Inverted repeat. The author has an hindex of 15, co-authored 22 publications receiving 821 citations. Previous affiliations of Colin Macaulay include Defence Research and Development Canada & University of Florida.
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Journal ArticleDOI
The complete DNA sequence of myxoma virus.
Cheryl M. Cameron,Cheryl M. Cameron,Sheela Hota-Mitchell,Ling Chen,John W. Barrett,Jing Xin Cao,Colin Macaulay,David O. Willer,David H. Evans,Grant McFadden,Grant McFadden +10 more
TL;DR: This work affirms the existence of a conserved complement of poxvirus-specific core genes and expands the growing repertoire of virus genes that confer the unique capacity of each poxVirus family member to counter the immune responses of the infected host.
Journal ArticleDOI
A Randomized Controlled, Phase 2 Trial of the Viral Serpin Serp-1 in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Jean-Claude Tardif,Philippe L. L’Allier,Jean Grégoire,Reda Ibrahim,Grant McFadden,William J. Kostuk,Merril L. Knudtson,Marino Labinaz,Ron Waksman,Carl J. Pepine,Colin Macaulay,Marie-Claude Guertin,Alexandra Lucas +12 more
TL;DR: A significant reduction in myocardial damage biomarkers supports further assessment of Serp-1 in ACS patients undergoing stent deployment and is the first study of a viral serpin demonstrating its safety in patients with percutaneous coronary intervention.
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Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection.
Erbin Dai,Li Ying Liu,Li Ying Liu,Hao Wang,Dana McIvor,Yun Ming Sun,Colin Macaulay,Elaine King,Ganesh Munuswamy-Ramanujam,Ganesh Munuswamy-Ramanujam,Mee Y Bartee,Jennifer Williams,Jennifer Davids,Israel F. Charo,Grant McFadden,Grant McFadden,Jeffrey D. Esko,Alexandra Lucas +17 more
TL;DR: Although chemokines direct both local and systemic cell migration, interruption of inherent chemokine responses in the donor tissue unexpectedly had a greater therapeutic impact on allograft vasculopathy.
Journal ArticleDOI
Physical characterization and molecular cloning of the Shope fibroma virus DNA genome
TL;DR: SFV sequences within this terminal region were shown, using 32P SFV cloned terminal probe, to have none of the sequence heterogeneity characteristic of vaccinia DNA termini.
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The target DNA sequence for resolution of poxvirus replicative intermediates is an active late promoter.
TL;DR: It is demonstrated that the TRT of SFV is capable of functioning as a strong viral promoter late in infection, and a spectrum of TRT mutations affects telomere resolution and late transcription in a strictly concordant fashion, suggesting that the two activities may be inextricably linked.