S
Sheela Hota-Mitchell
Researcher at University of Western Ontario
Publications - 5
Citations - 560
Sheela Hota-Mitchell is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Myxoma virus & Genome. The author has an hindex of 5, co-authored 5 publications receiving 548 citations. Previous affiliations of Sheela Hota-Mitchell include Robarts Research Institute.
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Journal ArticleDOI
The complete DNA sequence of myxoma virus.
Cheryl M. Cameron,Cheryl M. Cameron,Sheela Hota-Mitchell,Ling Chen,John W. Barrett,Jing Xin Cao,Colin Macaulay,David O. Willer,David H. Evans,Grant McFadden,Grant McFadden +10 more
TL;DR: This work affirms the existence of a conserved complement of poxvirus-specific core genes and expands the growing repertoire of virus genes that confer the unique capacity of each poxVirus family member to counter the immune responses of the infected host.
Journal ArticleDOI
Immunomodulation by viruses: the myxoma virus story
Piers Nash,John W. Barrett,Jing-Xin Cao,Sheela Hota-Mitchell,Alshad S. Lalani,Helen Everett,Xiao-Ming Xu,Janine Robichaud,Shawna Hnatiuk,Cheryl Ainslie,Bruce T. Seet,Grant McFadden +11 more
TL;DR: Two distinct viral strategies carried out by viral proteins with which myxoma virus subverts the host immune response are described, which can provide insights into virus‐host interactions and also provide new insights into the complex immune system.
Journal ArticleDOI
Immunomodulatory proteins of myxoma virus.
TL;DR: Some of the new open reading frames discovered during the sequencing of the myxoma virus DNA genome contain intriguing similarities to known cellular and viral proteins in the public domain for which immunomodulatory functions have been assigned.
Journal ArticleDOI
Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain.
Sheela Hota-Mitchell,Afzal A. Siddiqui,Gregory A. Dekaban,Gregory A. Dekaban,Jana Smith,Jana Smith,Cristina E. Tognon,Ronald B. Podesta +7 more
TL;DR: Evidence is presented for the protective capacity of several schistosomal antigen preparations, including a calcium binding protein of the APM, S. mansoni calpain, and data indicate that Sm-p80 may be a useful vaccine antigen for the reduction of the morbidity associated with S.mansoni infections of mammalian hosts.
Journal ArticleDOI
Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model.
Sheela Hota-Mitchell,Michael W. Clarke,Ronald B. Podesta,Gregory A. Dekaban,Gregory A. Dekaban +4 more
TL;DR: Preliminary in vivo studies demonstrate the potential for further study of the protection afforded by gene gun-delivered WRG-full5' mut p80 into subsequently-challenged mice and may pave the way to effective vaccination of humans using WRG DNA vectors expressing a schistosomal calcium-activated neutral protease.