Colin Reily

TL;DR: The broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’ are discussed.

TL;DR: Methods for assessing the impact of reactive species on isolated mitochondria are described using representative cell types from renal, cardiovascular, nervous, and tumorigenic model systems while illustrating the application of three protocols to analyze the bioenergetic response of cells to oxidative stress.

TL;DR: Findings show that the TPP+ moiety can disrupt mitochondrial function at concentrations frequently observed in cell culture and this behavior is dependent on the linker group and independent of antioxidant properties.

TL;DR: The hypothesis that mitochondrially targeted therapies may be beneficial in the treatment of diabetic nephropathy is supported and a relatively unexplored aspect of mitochondrial ROS signalling in the control of fibrosis is highlighted.

TL;DR: Glycosylation pathways associated with production of the autoantigen and the unique characteristics of the corresponding autoantibodies in patients with IgAN have been uncovered, and complement likely plays a significant role in the formation and the nephritogenic activities of these complexes.