C
Coline H.M. van Moorsel
Researcher at Utrecht University
Publications - 43
Citations - 1647
Coline H.M. van Moorsel is an academic researcher from Utrecht University. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Interstitial lung disease. The author has an hindex of 15, co-authored 43 publications receiving 990 citations.
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Journal ArticleDOI
Long-term expanding human airway organoids for disease modeling
Norman Sachs,Angelos Papaspyropoulos,Domenique D. Zomer-van Ommen,Inha Heo,Lena Böttinger,Dymph Klay,Fleur Weeber,Guizela Huelsz-Prince,Nino Iakobachvili,Gimano D. Amatngalim,Joep de Ligt,Arne Van Hoeck,Natalie Proost,Marco C. Viveen,Anna Lyubimova,Luc Teeven,Sepideh Derakhshan,Jeroen Korving,Harry Begthel,Johanna F. Dekkers,Kuldeep Kumawat,Emilio Ramos,Matthijs F.M. van Oosterhout,G. Johan A. Offerhaus,Dominique J Wiener,Eduardo P. Olimpio,Krijn K. Dijkstra,Egbert F. Smit,Maarten van der Linden,Sridevi Jaksani,Marieke van de Ven,Jos Jonkers,Anne C. Rios,Emile E. Voest,Coline H.M. van Moorsel,Cornelis K. van der Ent,Edwin Cuppen,Alexander van Oudenaarden,Frank E. J. Coenjaerts,Linde Meyaard,Louis Bont,Peter J. Peters,Sander J. Tans,Jeroen S. van Zon,Sylvia F. Boj,Robert G.J. Vries,Jeffrey M. Beekman,Hans Clevers +47 more
TL;DR: It is concluded that human airway organoids represent versatile models for the in vitro study of hereditary, malignant, and infectious pulmonary disease.
Journal ArticleDOI
Predicting Outcomes in Idiopathic Pulmonary Fibrosis Using Automated Computed Tomographic Analysis
Joseph Jacob,Brian J. Bartholmai,Srinivasan Rajagopalan,Coline H.M. van Moorsel,Hendrik W. van Es,Frouke T. van Beek,Marjolijn H. L. Struik,Maria Kokosi,Ryoko Egashira,Anne Laure Brun,Arjun Nair,Simon L.F. Walsh,Gary Cross,Joseph Barnett,Angelo De Lauretis,Eoin P. Judge,Sujal R. Desai,Ronald A. Karwoski,Sebastien Ourselin,Elisabetta A. Renzoni,Toby M. Maher,Andre Altmann,Athol U. Wells +22 more
TL;DR: This study has validated a new quantitative CT measure in patients with IPF fulfilling drug trial entry criteria—the VRS score—that outperformed current gold standard measures of outcome and can reduce a required IPF drug trial population size by 25%, thereby limiting prohibitive trial costs.
Journal ArticleDOI
Predicting outcomes in rheumatoid arthritis related interstitial lung disease.
Joseph Jacob,Nikhil Hirani,Coline H.M. van Moorsel,Srinivasan Rajagopalan,John T. Murchison,Hendrik W. van Es,Brian J. Bartholmai,Frouke T. van Beek,Marjolijn H. L. Struik,Gareth A. Stewart,Maria Kokosi,Ryoko Egashira,Anne Laure Brun,Gary Cross,Joseph Barnett,Anand Devaraj,George Margaritopoulos,Ronald A. Karwoski,Elisabetta A. Renzoni,Toby M. Maher,Athol U. Wells +20 more
TL;DR: The combination of two visual CT-based staging systems identified 23% of an RAILD cohort with an IPF-like progressive fibrotic phenotype and the addition of a computer-derived VRS threshold further improved outcome prediction and model fit, beyond that encompassed by RAILD measures of disease severity and extent.
Journal ArticleDOI
Telomere Length in Interstitial Lung Diseases
Reinier Snetselaar,Coline H.M. van Moorsel,Karin M. Kazemier,Joanne J. van der Vis,Pieter Zanen,Matthijs F.M. van Oosterhout,Jan C. Grutters +6 more
TL;DR: Short TL in the IPF and FIP-no mutation groups is indicative of an innate telomere-biology defect, while a stress-induced, acquired telomeres shortening might be the underlying process for the other ILD diagnoses.
Journal ArticleDOI
Short telomere length in IPF lung associates with fibrotic lesions and predicts survival.
Reinier Snetselaar,Aernoud A. van Batenburg,Matthijs F.M. van Oosterhout,Karin M. Kazemier,Suzan M Roothaan,Ton Peeters,Joanne J. van der Vis,Roel Goldschmeding,Jan C. Grutters,Coline H.M. van Moorsel +9 more
TL;DR: It was determined that IPF subjects with shortest lung TL had a significantly worse survival than patients with long TL, implying TL as a cause of fibrogenesis, and short lung telomere length is associated with decreased survival.