N
Nino Iakobachvili
Researcher at Maastricht University
Publications - 12
Citations - 1151
Nino Iakobachvili is an academic researcher from Maastricht University. The author has contributed to research in topics: Mycobacterium abscessus & Stem cell. The author has an hindex of 7, co-authored 10 publications receiving 646 citations. Previous affiliations of Nino Iakobachvili include Imperial College London.
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Journal ArticleDOI
Long-term expanding human airway organoids for disease modeling
Norman Sachs,Angelos Papaspyropoulos,Domenique D. Zomer-van Ommen,Inha Heo,Lena Böttinger,Dymph Klay,Fleur Weeber,Guizela Huelsz-Prince,Nino Iakobachvili,Gimano D. Amatngalim,Joep de Ligt,Arne Van Hoeck,Natalie Proost,Marco C. Viveen,Anna Lyubimova,Luc Teeven,Sepideh Derakhshan,Jeroen Korving,Harry Begthel,Johanna F. Dekkers,Kuldeep Kumawat,Emilio Ramos,Matthijs F.M. van Oosterhout,G. Johan A. Offerhaus,Dominique J Wiener,Eduardo P. Olimpio,Krijn K. Dijkstra,Egbert F. Smit,Maarten van der Linden,Sridevi Jaksani,Marieke van de Ven,Jos Jonkers,Anne C. Rios,Emile E. Voest,Coline H.M. van Moorsel,Cornelis K. van der Ent,Edwin Cuppen,Alexander van Oudenaarden,Frank E. J. Coenjaerts,Linde Meyaard,Louis Bont,Peter J. Peters,Sander J. Tans,Jeroen S. van Zon,Sylvia F. Boj,Robert G.J. Vries,Jeffrey M. Beekman,Hans Clevers +47 more
TL;DR: It is concluded that human airway organoids represent versatile models for the in vitro study of hereditary, malignant, and infectious pulmonary disease.
Journal ArticleDOI
Modelling Cryptosporidium infection in human small intestinal and lung organoids.
Inha Heo,Devanjali Dutta,Deborah A. Schaefer,Nino Iakobachvili,Benedetta Artegiani,Norman Sachs,Kim E Boonekamp,Gregory D. Bowden,Antoni P. A. Hendrickx,Robert J L Willems,Peter J. Peters,Michael W. Riggs,Roberta M. O'Connor,Hans Clevers +13 more
TL;DR: It is shown that Cryptosporidium can infect epithelial organoids derived from human small intestine and lung, where it replicates and completes its complex lifecycle.
Journal ArticleDOI
Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy
Else Driehuis,S. Kolders,Sacha Spelier,Kadi Lõhmussaar,Stefan M. Willems,Lot A. Devriese,Remco de Bree,Emma J de Ruiter,Jeroen Korving,Harry Begthel,Johan H. van Es,Veerle Geurts,Gui-Wei He,Richard H. van Jaarsveld,Rurika Oka,Mauro J. Muraro,Judith Vivié,Maurice M.J.M. Zandvliet,Antoni P. A. Hendrickx,Nino Iakobachvili,Priya Sridevi,Onno Kranenburg,Ruben van Boxtel,Geert J. P. L. Kops,David A. Tuveson,Peter J. Peters,Alexander van Oudenaarden,Hans Clevers +27 more
TL;DR: Conditions for long-term culture of human mucosal organoids derived from head and neck squamous cell carcinoma (HNSCC) are described and responses to therapies both currently used in the treatment of HNSCC and those not used in clinical practice are observed.
Journal ArticleDOI
Humans in a Dish: The Potential of Organoids in Modeling Immunity and Infectious Diseases.
TL;DR: It is believed organoid technology can be harnessed to study host–pathogen interactions resulting in a more physiologically relevant model that yields more predictive data of human infectious diseases than current systems.
Posted ContentDOI
Mycobacteria-host interactions in human bronchiolar airway organoids
Nino Iakobachvili,Stephen Adonai Leon Icaza,Kèvin Knoops,Norman Sachs,Serge Mazères,Roxane Simeone,Antonio Peixoto,Marlène Murris-Espin,Julien Mazieres,Carmen López-Iglesias,Raimond B. G. Ravelli,Olivier Neyrolles,Olivier Neyrolles,Etienne Meunier,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Hans Clevers,Céline Cougoule,Céline Cougoule,Peter J. Peters +19 more
TL;DR: It is concluded that adult stem cell–derived airway organoids can be used to model early events of tuberculosis infection and offer new avenues for fundamental and therapeutic research.