C
Constantinos Koumenis
Researcher at University of Pennsylvania
Publications - 156
Citations - 15751
Constantinos Koumenis is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Unfolded protein response & Tumor microenvironment. The author has an hindex of 52, co-authored 129 publications receiving 13837 citations. Previous affiliations of Constantinos Koumenis include Wake Forest University & Wake Forest Baptist Medical Center.
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Journal ArticleDOI
Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis.
TL;DR: The hypothesis that oncogenic signals in the absence of gene expression are sufficient to induce cell death is tested, which would indicate that constitutive expression of antiapoptotic genes is necessary for maintenance of the transformed state, and inhibition of RNAP II may be exploited therapeutically for the design of successful antitumor agents.
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Thioredoxin Reductase-1 Mediates Curcumin-Induced Radiosensitization of Squamous Carcinoma Cells
Prashanthi Javvadi,Lauren Hertan,Rachelle Kosoff,Tatini Datta,Johann Kolev,Rosemarie Mick,Stephen W. Tuttle,Constantinos Koumenis +7 more
TL;DR: It is reported that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required forCurcumin-mediated radiosensitization of squamous carcinoma cells and suggested that TxnRD1 levels in tumors could have clinical value as a predictor of response to curcuming and radiotherapy.
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A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival
Yiwen Bu,Akihiro Yoshida,Nilesh Chitnis,Brian J. Altman,Feven Tameire,Amanda R. Oran,Victoria J. Gennaro,Kent Armeson,Steven B. McMahon,Gerald Wertheim,Chi V. Dang,Davide Ruggero,Constantinos Koumenis,Serge Y. Fuchs,J. Alan Diehl +14 more
TL;DR: It is demonstrated that c-Myc-dependent activation of the UPR inhibits Bmal1 in Burkitt’s lymphoma, thereby suppressing both circadian oscillation and ongoing protein synthesis to facilitate tumour progression.
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Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy.
TL;DR: The main mechanisms by which tumor cells overcome ER stress to promote their survival, tumor progression and metastasis are described and the current state of efforts to develop therapeutic approaches of targeting the UPR are discussed.
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c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma
Menggui Huang,Tianrun Liu,Peihong Ma,R. Alan Mitteer,Zhenting Zhang,Hyun Jun Kim,Eujin Yeo,Duo Zhang,Pei-Qiang Cai,Chunsheng Li,Lin Zhang,Botao Zhao,Laura Roccograndi,Donald M. O'Rourke,Nadia Dahmane,Yanqing Gong,Constantinos Koumenis,Yi Fan +17 more
TL;DR: Findings illustrate a mechanism that controls aberrant tumor vascularization and suggest that targeting Endo-MT may offer selective and efficient strategies for antivascular and vessel normalization therapies in GBM, and possibly other malignant tumors.