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Constantinos Koumenis

Researcher at University of Pennsylvania

Publications -  156
Citations -  15751

Constantinos Koumenis is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Unfolded protein response & Tumor microenvironment. The author has an hindex of 52, co-authored 129 publications receiving 13837 citations. Previous affiliations of Constantinos Koumenis include Wake Forest University & Wake Forest Baptist Medical Center.

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Journal ArticleDOI

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

Lori S. Hart, +6 more
- 15 Jul 2011 - 
TL;DR: A novel role for IGF-1 is identified in the enrichment of chemo-resistant CSC populations in colon cancer cell lines in vitro and in vivo and may complement current standard chemotherapeutic regimens that target cycling cells.
Journal ArticleDOI

Molecular approaches to understanding circadian oscillations

Joseph S. Takahashi, +3 more
- 01 Jan 1993 - 
TL;DR: Answering this question will entail discovery of the molecules that comprise the circadian oscillator and the determination of how these molecules interact with one another to generate a circadian oscillation.
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Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Daniel J. Klionsky, +2522 more
- 01 Jan 2016 - 
TL;DR: Author(s): Klionsky, DJ; Abdelmohsen, K; Abe, A; Abedin, MJ; Abeliovich, H; A Frozena, AA; Adachi, H, Adeli, K, Adhihetty, PJ; Adler, SG; Agam, G; Agarwal, R; Aghi, MK; Agnello, M; Agostinis, P; Aguilar, PV; Aguirre-Ghis
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FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response.

Anastasia Velalopoulou, +29 more
- 15 Sep 2021 - 
TL;DR: In this paper, the authors studied the effects of FLASH-proton radiotherapy (F-PRT) on skin and mesenchymal tissues of muscle and bone in the C57BL/6 murine hind leg.
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The Adenovirus E4orf6 Protein Inhibits DNA Double Strand Break Repair and Radiosensitizes Human Tumor Cells in an E1B-55K-independent Manner

Lori S. Hart, +8 more
- 14 Jan 2005 - 
TL;DR: It is demonstrated for the first time that E4orf6 expression hinders the cellular DNA repair process in mammalian cells in the absence of E1B-55K or other adenoviral genes and suggested that viral-mediated delivery of E4orc6, combined with localized external beam radiation, could be a useful approach for the treatment of radioresistant solid tumors such as glioblastomas.