C
Constantinos Koumenis
Researcher at University of Pennsylvania
Publications - 156
Citations - 15751
Constantinos Koumenis is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Unfolded protein response & Tumor microenvironment. The author has an hindex of 52, co-authored 129 publications receiving 13837 citations. Previous affiliations of Constantinos Koumenis include Wake Forest University & Wake Forest Baptist Medical Center.
Papers
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Journal ArticleDOI
Pro-tumorigenic AMPK in glioblastoma
TL;DR: It is shown that glioma stem cells co-opt an AMPK-dependent pathway to rewire metabolism, promoting tumour growth.
Journal ArticleDOI
Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer.
Christoforos Thomas,Ilias V. Karagounis,Ratnesh Kumar Srivastava,Nicholas Vrettos,Fotis Nikolos,Noelle Francois,Menggui Huang,Siliang Gong,Qi Long,Sushil Kumar,Constantinos Koumenis,Savitri Krishnamurthy,Naoto T. Ueno,Rumela Chakrabarti,Amit Maity +14 more
TL;DR: In this article, the role of the second ER subtype, ERβ, and its correlation with reduced metastasis was explored, and the ability of the receptor to inhibit dissemination of IBC cells and prevent metastasis.
Patent
Novel Compounds for Treatment of Malignant Tumors
TL;DR: In this paper, the authors present compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer.
Journal ArticleDOI
The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells.
TL;DR: It is found that genetic ablation of Perk does not suppress the generation of the leukemic cells in the bone marrow, and the cell-autonomous Perk deficiency restricts the dissemination of leukedmic cells into peripheral blood, lymph nodes, and vital peripheral organs.
Proceedings ArticleDOI
Abstract B05: PI3K/mTOR pathway-dependent regulation of oxygen metabolism via pyruvate dehydrogenase (PDH)-E1alpha phosphorylation
George J. Cerniglia,Souvik Dey,Shannon M. Gallagher-Colombo,Natalie A. Daurio,Stephen W. Tuttle,Theresa M. Busch,Alexander Lin,Tatiana V. Esipova,Sergei A. Vinogradov,Constantinos Koumenis,Amit Maity +10 more
TL;DR: It is shown that pharmacological inhibition of this pathway leads to a decrease in hypoxia within SQ20B human head and neck cancer xenografts and a novel link between this pathway and PDH phosphorylation is revealed.