J
Jeroen Kuipers
Researcher at University Medical Center Groningen
Publications - 63
Citations - 8278
Jeroen Kuipers is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Gene & Fluidized bed. The author has an hindex of 25, co-authored 55 publications receiving 7203 citations. Previous affiliations of Jeroen Kuipers include University of Groningen & Utrecht University.
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Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
Journal ArticleDOI
Mutations in the APC tumour suppressor gene cause chromosomal instability
Riccardo Fodde,Jeroen Kuipers,Jeroen Kuipers,Carla Rosenberg,Ron Smits,Menno F. Kielman,Claudia Gaspar,Johan H. van Es,Cor Breukel,Joop Wiegant,Rachel H. Giles,Hans Clevers +11 more
TL;DR: It is concluded that loss of APC sequences that lie C-terminal to the β-catenin regulatory domain contributes to chromosomal instability in colorectal cancer.
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Complete Polarization of Single Intestinal Epithelial Cells upon Activation of LKB1 by STRAD
Annette F. Baas,Jeroen Kuipers,Nicole N. van der Wel,Eduard Batlle,Henk K. Koerten,Peter J. Peters,Hans Clevers +6 more
TL;DR: It is concluded that LKB1 can induce complete polarity in intestinal epithelial cells, in contrast to current thinking on polarization of simple epithelia, these cells can fully polarize in the absence of junctional cell-cell contacts.
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Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function
Martijn F Hoes,Niels Grote Beverborg,J David Kijlstra,Jeroen Kuipers,Dorine W. Swinkels,Ben N G Giepmans,Richard J. Rodenburg,Dirk J. van Veldhuisen,Rudolf A. de Boer,Peter van der Meer +9 more
TL;DR: This study aims to determine the direct effects of iron deficiency and iron repletion on human cardiomyocytes.
Journal ArticleDOI
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
Martti Maimets,Cecilia Rocchi,Reinier Bron,Sarah Pringle,Jeroen Kuipers,Ben N G Giepmans,Robert G.J. Vries,Hans Clevers,Gerald de Haan,Ronald van Os,Robert P. Coppes +10 more
TL;DR: It is reported that rare SG ductal EpCAM+ cells express nuclear β-catenin, indicating active Wnt signaling, allowing extensive in vitro expansion and enabling restoration of SG function upon transplantation.