M
Maiying Kong
Researcher at University of Louisville
Publications - 116
Citations - 2698
Maiying Kong is an academic researcher from University of Louisville. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 24, co-authored 87 publications receiving 1953 citations. Previous affiliations of Maiying Kong include University of Texas MD Anderson Cancer Center & Indiana University.
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Journal ArticleDOI
Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment.
Lara M. Bull-Otterson,Wenke Feng,Irina A. Kirpich,Yuhua Wang,Xiang Qin,Yanlong Liu,Leila Gobejishvili,Swati Joshi-Barve,Tulin Ayvaz,Joseph F. Petrosino,Maiying Kong,David F. Barker,Craig J. McClain,Shirish Barve +13 more
TL;DR: Overall, significant alterations in the gut microbiome over time occur in response to chronic alcohol exposure and correspond to increases in intestinal barrier dysfunction and development of ALD.
Journal ArticleDOI
The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.
Steven P. Jones,Xian Liang Tang,Yiru Guo,Charles Steenbergen,David J. Lefer,Rakesh C. Kukreja,Maiying Kong,Qianhong Li,Shashi Bhushan,Xiaoping Zhu,Junjie Du,Yibing Nong,Heather Stowers,Kazuhisa Kondo,Gregory N. Hunt,Traci T. Goodchild,Adam Orr,Carlos C. Chang,Ramzi A Ockaili,Fadi N Salloum,Roberto Bolli +20 more
TL;DR: CAESAR is operational, generates reproducible results, can detect cardioprotection, and provides a mechanism for assessing potential infarct-sparing therapies with a level of rigor analogous to multicenter, randomized, controlled clinical trials.
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Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.
Zhiguo Zhang,Zhiguo Zhang,Shudong Wang,Shudong Wang,Shanshan Zhou,Shanshan Zhou,Xiaoqing Yan,Xiaoqing Yan,Yonggang Wang,Yonggang Wang,Jing Chen,Nicholas M. Mellen,Maiying Kong,Junlian Gu,Junlian Gu,Yi Tan,Yi Tan,Yang Zheng,Lu Cai,Lu Cai +19 more
TL;DR: It is suggested that SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2 DM-induced lipotoxicity and cardiomyopathy.
Journal ArticleDOI
Interaction Index and Different Methods for Determining Drug Interaction in Combination Therapy
TL;DR: A procedure to calculate the interaction index and its associated confidence interval is proposed under the assumption that the dose-effect curve for a single agent follows Chou and Talalay's median effect equation.
Journal ArticleDOI
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.
Samantha M. Morrissey,Fan Zhang,Chuanlin Ding,Diego E. Montoya-Durango,Xiaoling Hu,Chenghui Yang,Zhen Wang,Fang Yuan,Matthew P. Fox,Huang-Ge Zhang,Haixun Guo,David Tieri,Maiying Kong,Corey T. Watson,Robert A. Mitchell,Xiang Zhang,Kelly M. McMasters,Jian Huang,Jun Yan +18 more
TL;DR: In this article, the authors demonstrate that tumor-derived exosomes polarize macrophages toward an immunosuppressive phenotype characterized by increased PD-L1 expression through NF-kB-dependent, glycolytic-dominant metabolic reprogramming.