C
Catharine M. Bosio
Researcher at National Institutes of Health
Publications - 87
Citations - 6046
Catharine M. Bosio is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Francisella tularensis & Medicine. The author has an hindex of 33, co-authored 72 publications receiving 5017 citations. Previous affiliations of Catharine M. Bosio include United States Department of the Army & Colorado State University.
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Journal ArticleDOI
A Tn7-based broad-range bacterial cloning and expression system
Kyoung-Hee Choi,Jared B. Gaynor,Kimberly G. White,Carolina M. López,Catharine M. Bosio,RoxAnn R. Karkhoff-Schweizer,Herbert P. Schweizer +6 more
TL;DR: The Tn7 system allows engineering of diverse genetic traits into bacteria, as demonstrated by complementing a biofilm-growth defect of P. aeruginosa, establishing expression systems in P. putida and Yersinia pestis, and 'GFP-tagging' Y. pestis.
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Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Brandi N. Williamson,Friederike Feldmann,Benjamin Schwarz,Kimberly Meade-White,Danielle P. Porter,Jonathan E Schulz,Neeltje van Doremalen,Ian Leighton,Claude Kwe Yinda,Lizzette Pérez-Pérez,Atsushi Okumura,Jamie Lovaglio,Patrick W. Hanley,Greg Saturday,Catharine M. Bosio,Sarah L. Anzick,Kent D. Barbian,Tomas Cihlar,Craig Martens,Dana P. Scott,Vincent J. Munster,Emmie de Wit +21 more
TL;DR: The data support the early initiation of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia and reduce viral load and lung disease in a rhesus macaque model of SARS-CoV-2 infection.
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Lipid Raft Microdomains A Gateway for Compartmentalized Trafficking of Ebola and Marburg Viruses
Sina Bavari,Catharine M. Bosio,Elizabeth Wiegand,Gordon Ruthel,Amy B. Will,Thomas W. Geisbert,Michael Hevey,Connie S. Schmaljohn,Alan L. Schmaljohn,M. Javad Aman +9 more
TL;DR: The compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding is reported, suggesting that viral exit occurs at the rafts and that the entry of filoviruses requires functional rafts.
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Ebola and Marburg Viruses Replicate in Monocyte-Derived Dendritic Cells without Inducing the Production of Cytokines and Full Maturation
Catharine M. Bosio,M. Javad Aman,Case C. Grogan,Robert J. Hogan,Gordon Ruthel,Diane L. Negley,Mansour Mohamadzadeh,Sina Bavari,Alan L. Schmaljohn +8 more
TL;DR: It is demonstrated that EBOV and MARV infected and replicated in primary human DCs without inducing cytokine secretion, and DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms.
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Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes.
Karen Zaks,Michael B. Jordan,Amanda Guth,K. Sellins,Ross M. Kedl,Angelo Izzo,Catharine M. Bosio,Steven W. Dow +7 more
TL;DR: Results suggest that certain TLR agonists can be combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.