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Atsushi Okumura
Researcher at National Institutes of Health
Publications - 138
Citations - 11506
Atsushi Okumura is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Cherenkov Telescope Array. The author has an hindex of 44, co-authored 125 publications receiving 9442 citations. Previous affiliations of Atsushi Okumura include Johns Hopkins University & Sony Broadcast & Professional Research Laboratories.
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Journal ArticleDOI
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques.
Neeltje van Doremalen,Teresa Lambe,Alexandra J. Spencer,Sandra Belij-Rammerstorfer,Jyothi N. Purushotham,Jyothi N. Purushotham,Julia R Port,Victoria A. Avanzato,Trenton Bushmaker,Amy Flaxman,Marta Ulaszewska,Friederike Feldmann,Elizabeth R. Allen,Hannah Sharpe,Jonathan E Schulz,Myndi G. Holbrook,Atsushi Okumura,Kimberly Meade-White,Lizzette Pérez-Pérez,Nick J. Edwards,Daniel B. Wright,Cameron Bissett,Ciaran Gilbride,Brandi N. Williamson,Rebecca Rosenke,Dan Long,Alka Ishwarbhai,Reshma Kailath,Louisa Rose,Susan J. Morris,Claire Powers,Jamie Lovaglio,Patrick W. Hanley,Dana P. Scott,Greg Saturday,Emmie de Wit,Sarah C. Gilbert,Vincent J. Munster +37 more
TL;DR: It is shown that the adenovirus-vector-based vaccine ChAdOx1 nCoV-19, which encodes the spike protein of SARS- CoV-2, is immunogenic in mice and elicites a robust humoral and cell-mediated response.
Journal ArticleDOI
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.
Emmie de Wit,Friederike Feldmann,Jacqueline Cronin,Robert Jordan,Atsushi Okumura,Tina Thomas,Dana P. Scott,Tomas Cihlar,Heinz Feldmann +8 more
TL;DR: The data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials, and may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.
Journal ArticleDOI
Fermi Observations of High-Energy Gamma-Ray Emission from GRB 080916C
Markus Ackermann,Marco Ajello,Luca Baldini,Jean Ballet,Guido Barbiellini,Guido Barbiellini,Matthew G. Baring,Denis Bastieri,Denis Bastieri,Keith Bechtol,Ronaldo Bellazzini,B. Berenji,P. N. Bhat,Elisabetta Bissaldi,Roger Blandford,Emanuele Bonamente,Emanuele Bonamente,A. W. Borgland,A. Bouvier,Johan Bregeon,Alessandro Brez,Michael S. Briggs,M. Brigida,M. Brigida,P. Bruel,R. Buehler,S. Buson,S. Buson,G. A. Caliandro,R. A. Cameron,P. A. Caraveo,S. Carrigan,J. M. Casandjian,C. Cecchi,C. Cecchi,Omer Celik,Omer Celik,Eric Charles,A. Chekhtman,A. Chekhtman,J. Chiang,Stefano Ciprini,R. Claus,Johann Cohen-Tanugi,Valerie Connaughton,J. Conrad,J. Conrad,S. Cutini,C. D. Dermer,A. De Angelis,F. de Palma,F. de Palma,Seth Digel,E. Do Couto E Silva,Persis S. Drell,R. Dubois,C. Favuzzi,C. Favuzzi,Stephen Fegan,Elizabeth C. Ferrara,M. Frailis,Yasushi Fukazawa,P. Fusco,P. Fusco,F. Gargano,Dario Gasparrini,Neil Gehrels,S. Germani,S. Germani,Nicola Giglietto,Nicola Giglietto,Paolo Giommi,F. Giordano,F. Giordano,Marcello Giroletti,T. Glanzman,G. Godfrey,Jonathan Granot,I. A. Grenier,J. E. Grove,L. Guillemot,L. Guillemot,L. Guillemot,Sylvain Guiriec,D. Hadasch,E. Hays,D. Horan,R. E. Hughes,Gudlaugur Johannesson,A. S. Johnson,W. N. Johnson,T. Kamae,Hideaki Katagiri,R. M. Kippen,Jürgen Knödlseder,D. Kocevski,M. Kuss,J. Lande,L. Latronico,Shiu-Hang Lee,M. Llena Garde,Francesco Longo,Francesco Longo,F. Loparco,F. Loparco,M. N. Lovellette,P. Lubrano,P. Lubrano,A. Makeev,A. Makeev,M. N. Mazziotta,S. McBreen,S. McBreen,Julie McEnery,Julie McEnery,S. McGlynn,S. McGlynn,Charles A. Meegan,J. Mehault,Peter Mészáros,Peter F. Michelson,Tsunefumi Mizuno,A. A. Moiseev,A. A. Moiseev,C. Monte,C. Monte,M. E. Monzani,Elena Moretti,Elena Moretti,A. Morselli,Igor V. Moskalenko,S. Murgia,Hiroshi Nakajima,Takeshi Nakamori,M. Naumann-Godo,P. L. Nolan,J. P. Norris,E. Nuss,Masanori Ohno,T. Ohsugi,Atsushi Okumura,Nicola Omodei,E. Orlando,Jonathan F. Ormes,M. Ozaki,W. S. Paciesas,David Paneque,J. H. Panetta,D. Parent,D. Parent,V. Pelassa,M. Pepe,M. Pepe,Melissa Pesce-Rollins,Vahé Petrosian,F. Piron,T. A. Porter,Robert D. Preece,Judith Racusin,S. Rainò,S. Rainò,Robert R. Rando,Robert R. Rando,Arne Rau,M. Razzano,Soebur Razzaque,Soebur Razzaque,A. Reimer,Olaf Reimer,J. Ripken,M. Roth,Felix Ryde,Felix Ryde,Hartmut Sadrozinski,A. Sander,Jeffrey D. Scargle,T. L. Schalk,Carmelo Sgrò,E. J. Siskind,P. D. Smith,Gloria Spandre,P. Spinelli,P. Spinelli,Michael Stamatikos,Michael Stamatikos,M. S. Strickman,D. J. Suson,Hiroyasu Tajima,Hiromitsu Takahashi,Takaaki Tanaka,J. B. Thayer,J. G. Thayer,L. Tibaldo,Diego F. Torres,Diego F. Torres,Gino Tosti,Gino Tosti,A. Tramacere,T. Uehara,T. L. Usher,Justin Vandenbroucke,A. J. van der Horst,V. Vasileiou,V. Vasileiou,N. Vilchez,V. Vitale,V. Vitale,A. von Kienlin,A. P. Waite,P. Wang,Colleen A. Wilson-Hodge,B. L. Winer,Kent S. Wood,Xue-Feng Wu,Xue-Feng Wu,Ryo Yamazaki,Zhenwei Yang,T. Ylinen,T. Ylinen,M. Ziegler +219 more
TL;DR: The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gammaray energy, with the largest apparent energy release yet measured.
Journal ArticleDOI
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
Vincent J. Munster,Friederike Feldmann,Brandi N. Williamson,Neeltje van Doremalen,Lizzette Pérez-Pérez,Jonathan E Schulz,Kimberly Meade-White,Atsushi Okumura,Julie Callison,Beniah Brumbaugh,Victoria A. Avanzato,Rebecca Rosenke,Patrick W. Hanley,Greg Saturday,Dana P. Scott,Elizabeth R. Fischer,Emmie de Wit +16 more
TL;DR: It is shown that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days, which recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19.
Journal ArticleDOI
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2.
Brandi N. Williamson,Friederike Feldmann,Benjamin Schwarz,Kimberly Meade-White,Danielle P. Porter,Jonathan E Schulz,Neeltje van Doremalen,Ian Leighton,Claude Kwe Yinda,Lizzette Pérez-Pérez,Atsushi Okumura,Jamie Lovaglio,Patrick W. Hanley,Greg Saturday,Catharine M. Bosio,Sarah L. Anzick,Kent D. Barbian,Tomas Cihlar,Craig Martens,Dana P. Scott,Vincent J. Munster,Emmie de Wit +21 more
TL;DR: The data support the early initiation of remdesivir treatment in patients with COVID-19 to prevent progression to pneumonia and reduce viral load and lung disease in a rhesus macaque model of SARS-CoV-2 infection.