C
Cristian Tomasetti
Researcher at Johns Hopkins University
Publications - 72
Citations - 9641
Cristian Tomasetti is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 26, co-authored 65 publications receiving 6758 citations. Previous affiliations of Cristian Tomasetti include University of Sydney & University of Maryland, College Park.
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Journal ArticleDOI
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Joshua D. Cohen,Lu Li,Yuxuan Wang,Christopher J. Thoburn,Bahman Afsari,Ludmila Danilova,Christopher Douville,Ammar A. Javed,Fay Wong,Austin Mattox,Ralph H. Hruban,Ralph H. Hruban,Christopher L. Wolfgang,Michael Goggins,Marco Dal Molin,Tian Li Wang,Tian Li Wang,Richard B.S. Roden,Richard B.S. Roden,Alison P. Klein,Alison P. Klein,Janine Ptak,Lisa Dobbyn,Joy Schaefer,Natalie Silliman,Maria Popoli,Joshua T. Vogelstein,J.D. Browne,Robert E. Schoen,Randall E. Brand,Jeanne Tie,Peter Gibbs,Hui-Li Wong,Aaron S. Mansfield,Jin Jen,Samir M. Hanash,Massimo Falconi,Peter J. Allen,Shibin Zhou,Chetan Bettegowda,Luis A. Diaz,Cristian Tomasetti,Cristian Tomasetti,Kenneth W. Kinzler,Bert Vogelstein,Anne Marie Lennon,Nickolas Papadopoulos +46 more
TL;DR: A blood test that combines protein and DNA markers may allow earlier detection of eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA.
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Variation in cancer risk among tissues can be explained by the number of stem cell divisions
TL;DR: It is shown that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis, suggesting that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions.
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Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Jeanne Tie,Yuxuan Wang,Cristian Tomasetti,Cristian Tomasetti,Lu Li,Simeon Springer,Isaac Kinde,Natalie Silliman,Mark Tacey,Hui-Li Wong,Hui-Li Wong,Michael Christie,Michael Christie,Suzanne Kosmider,Iain Skinner,Rachel Wong,Rachel Wong,Malcolm Steel,Ben Tran,Jayesh Desai,Jayesh Desai,Ian T. Jones,Ian T. Jones,Andrew Haydon,Theresa M. Hayes,Timothy J. Price,Robert L. Strausberg,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Peter Gibbs +31 more
TL;DR: It is shown that the presence of circulating tumor DNA in a patient’s blood after surgery is a sign of persistent tumor and a greatly increased risk of relapse, suggesting that this group of patients may require chemotherapy to prevent recurrence.
Journal ArticleDOI
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
TL;DR: In this article, the authors studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world and revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cells divisions in all countries, regardless of their environment.
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Cancer-Associated Mutations in Endometriosis without Cancer
Michael S. Anglesio,Nickolas Papadopoulos,Ayse Ayhan,Tayyebeh M. Nazeran,Michaël Noë,Hugo M. Horlings,Amy Lum,Siân Jones,Janine Senz,Tamer Seckin,Julie Ho,Ren-Chin Wu,Vivian Lac,Hiroshi Ogawa,Basile Tessier-Cloutier,Rami Alhassan,Amy Wang,Yuxuan Wang,Joshua D. Cohen,Fontayne Wong,Adnan Hasanovic,Natasha L. Orr,Ming Zhang,Maria Popoli,Wyatt Mcmahon,Laura D. Wood,Austin Mattox,Catherine Allaire,James H. Segars,Christina Williams,Cristian Tomasetti,Niki Boyd,Kenneth W. Kinzler,C. Blake Gilks,Luis A. Diaz,Tian Li Wang,Bert Vogelstein,Paul J. Yong,David G. Huntsman,Ie Ming Shih +39 more
TL;DR: It is found that lesions in deep infiltrating endometriosis, which are associated with virtually no risk of malignant transformation, harbor somatic cancer driver mutations.