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Isaac Kinde
Researcher at Johns Hopkins University School of Medicine
Publications - 32
Citations - 12740
Isaac Kinde is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 25, co-authored 32 publications receiving 10649 citations. Previous affiliations of Isaac Kinde include University of Maryland, Baltimore County & Medical University of Vienna.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
Luis A. Diaz,Luis A. Diaz,Richard Thomas Williams,Jian Wu,Jian Wu,Isaac Kinde,J. Randolph Hecht,Jordan Berlin,Benjamin L. Allen,Ivana Bozic,Johannes G. Reiter,Johannes G. Reiter,Martin A. Nowak,Kenneth W. Kinzler,Kelly S. Oliner,Bert Vogelstein +15 more
TL;DR: Results suggest that the emergence of KRAS mutations is a mediator of acquired resistance to EGFR blockade and that these mutations can be detected in a non-invasive manner, which explains why solid tumours develop resistance to targeted therapies in a highly reproducible fashion.
Journal ArticleDOI
Detection of circulating tumor dna in early and late stage human malignancies
Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Nishant Agrawal,Bjarne Bartlett,Hao Wang,Brandon Luber,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos +10 more
TL;DR: Digital PCR-based technologies used to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types suggest that ctDNA is a sensitive, specific and robust biomarker that can be used for a variety of clinical and research purposes in patients with several multiple different types of cancer.
Journal ArticleDOI
Detection and quantification of rare mutations with massively parallel sequencing
TL;DR: An approach that can substantially increase the sensitivity of massively parallel sequencing instruments for the identification of rare variants and the utility of this approach for determining the fidelity of a polymerase, the accuracy of oligonucleotides synthesized in vitro, and the prevalence of mutations in the nuclear and mitochondrial genomes of normal cells is described.
Journal ArticleDOI
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Jeanne Tie,Yuxuan Wang,Cristian Tomasetti,Cristian Tomasetti,Lu Li,Simeon Springer,Isaac Kinde,Natalie Silliman,Mark Tacey,Hui-Li Wong,Hui-Li Wong,Michael Christie,Michael Christie,Suzanne Kosmider,Iain Skinner,Rachel Wong,Rachel Wong,Malcolm Steel,Ben Tran,Jayesh Desai,Jayesh Desai,Ian T. Jones,Ian T. Jones,Andrew Haydon,Theresa M. Hayes,Timothy J. Price,Robert L. Strausberg,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Peter Gibbs +31 more
TL;DR: It is shown that the presence of circulating tumor DNA in a patient’s blood after surgery is a sign of persistent tumor and a greatly increased risk of relapse, suggesting that this group of patients may require chemotherapy to prevent recurrence.