M
Marco Dal Molin
Researcher at Johns Hopkins University School of Medicine
Publications - 57
Citations - 6162
Marco Dal Molin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Pancreatic cancer & Intraductal papillary mucinous neoplasm. The author has an hindex of 28, co-authored 50 publications receiving 4879 citations. Previous affiliations of Marco Dal Molin include University of Verona & University of Maryland, Baltimore.
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Journal ArticleDOI
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Joshua D. Cohen,Lu Li,Yuxuan Wang,Christopher J. Thoburn,Bahman Afsari,Ludmila Danilova,Christopher Douville,Ammar A. Javed,Fay Wong,Austin Mattox,Ralph H. Hruban,Ralph H. Hruban,Christopher L. Wolfgang,Michael Goggins,Marco Dal Molin,Tian Li Wang,Tian Li Wang,Richard B.S. Roden,Richard B.S. Roden,Alison P. Klein,Alison P. Klein,Janine Ptak,Lisa Dobbyn,Joy Schaefer,Natalie Silliman,Maria Popoli,Joshua T. Vogelstein,J.D. Browne,Robert E. Schoen,Randall E. Brand,Jeanne Tie,Peter Gibbs,Hui-Li Wong,Aaron S. Mansfield,Jin Jen,Samir M. Hanash,Massimo Falconi,Peter J. Allen,Shibin Zhou,Chetan Bettegowda,Luis A. Diaz,Cristian Tomasetti,Cristian Tomasetti,Kenneth W. Kinzler,Bert Vogelstein,Anne Marie Lennon,Nickolas Papadopoulos +46 more
TL;DR: A blood test that combines protein and DNA markers may allow earlier detection of eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA.
Journal ArticleDOI
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Jian Wu,Hanno Matthaei,Anirban Maitra,Marco Dal Molin,Laura D. Wood,James R. Eshleman,Michael Goggins,Marcia I. Canto,Richard D. Schulick,Barish H. Edil,Christopher L. Wolfgang,Alison P. Klein,Luis A. Diaz,Peter J. Allen,C. Max Schmidt,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Bert Vogelstein +18 more
TL;DR: It is determined that the presence of mutations in two oncogenes can identify the cysts that are likely to progress to carcinoma and so are good candidates for surgical removal, and suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions.
Journal ArticleDOI
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
Jian Wu,Yuchen Jiao,Marco Dal Molin,Anirban Maitra,Roeland F. de Wilde,Laura D. Wood,James R. Eshleman,Michael Goggins,Christopher L. Wolfgang,Marcia I. Canto,Richard D. Schulick,Barish H. Edil,Michael A. Choti,Volkan Adsay,David S. Klimstra,G. Johan A. Offerhaus,Alison P. Klein,Levy Kopelovich,Hannah Carter,Rachel Karchin,Peter J. Allen,C. Max Schmidt,Yoshiki Naito,Luis A. Diaz,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Bert Vogelstein +27 more
TL;DR: The preponderance of inactivating mutations in RNF43 unequivocally establish it as a suppressor of both IPMNs and MCNs, highlighting the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors.
Journal ArticleDOI
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers
Joshua D. Cohen,Ammar A. Javed,Christopher J. Thoburn,Fay Wong,Jeanne Tie,Jeanne Tie,Peter Gibbs,Peter Gibbs,C. Max Schmidt,Michele T. Yip-Schneider,Peter J. Allen,Mark A. Schattner,Randall E. Brand,Aatur D. Singhi,Gloria M. Petersen,Seung-Mo Hong,Song Cheol Kim,Massimo Falconi,Claudio Doglioni,Matthew J. Weiss,Nita Ahuja,Jin He,Martin A. Makary,Anirban Maitra,Samir M. Hanash,Marco Dal Molin,Yuxuan Wang,Lu Li,Janine Ptak,Lisa Dobbyn,Joy Schaefer,Natalie Silliman,Maria Popoli,Michael Goggins,Ralph H. Hruban,Christopher L. Wolfgang,Alison P. Klein,Cristian Tomasetti,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Anne Marie Lennon +41 more
TL;DR: It is shown how combining mutations in circulating tumor DNA (ctDNA) with protein markers can result in a screening test with improved sensitivity while retaining specificity, which may prove useful for the earlier detection of many cancer types.
Journal ArticleDOI
A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts
Simeon Springer,Yuxuan Wang,Marco Dal Molin,David L. Masica,Yuchen Jiao,Isaac Kinde,Amanda L. Blackford,Siva P. Raman,Christopher L. Wolfgang,Tyler M. Tomita,Noushin Niknafs,Christopher Douville,Janine Ptak,Lisa Dobbyn,Peter J. Allen,David S. Klimstra,Mark A. Schattner,C. Max Schmidt,Michele T. Yip-Schneider,Oscar W. Cummings,Randall E. Brand,Herbert J. Zeh,Aatur D. Singhi,Aldo Scarpa,Roberto Salvia,Giuseppe Malleo,Giuseppe Zamboni,Massimo Falconi,Jin-Young Jang,Sun Whe Kim,Wooil Kwon,Seung-Mo Hong,Ki Byung Song,Song Cheol Kim,Niall Swan,Jean Murphy,Justin Geoghegan,William R. Brugge,Carlos Fernandez-del Castillo,Mari Mino-Kenudson,Richard D. Schulick,Barish H. Edil,Volkan Adsay,Jorge Paulino,Jeanin E. van Hooft,Shinichi Yachida,Satoshi Nara,Nobuyoshi Hiraoka,Kenji Yamao,Susuma Hijioka,Schalk Van der Merwe,Michael Goggins,Marcia I. Canto,Nita Ahuja,Kenzo Hirose,Martin A. Makary,Matthew J. Weiss,John L. Cameron,Meredith E. Pittman,James R. Eshleman,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Rachel Karchin,Ralph H. Hruban,Bert Vogelstein,Anne Marie Lennon +66 more
TL;DR: A panel of molecular markers and clinical features that show promise for the accurate classification of cystic neoplasms of the pancreas and identification of cysts that require surgery are identified.