A
Austin Mattox
Researcher at Johns Hopkins University School of Medicine
Publications - 19
Citations - 2517
Austin Mattox is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 7, co-authored 13 publications receiving 1747 citations. Previous affiliations of Austin Mattox include Johns Hopkins University.
Papers
More filters
Journal ArticleDOI
Detection and localization of surgically resectable cancers with a multi-analyte blood test
Joshua D. Cohen,Lu Li,Yuxuan Wang,Christopher J. Thoburn,Bahman Afsari,Ludmila Danilova,Christopher Douville,Ammar A. Javed,Fay Wong,Austin Mattox,Ralph H. Hruban,Ralph H. Hruban,Christopher L. Wolfgang,Michael Goggins,Marco Dal Molin,Tian Li Wang,Tian Li Wang,Richard B.S. Roden,Richard B.S. Roden,Alison P. Klein,Alison P. Klein,Janine Ptak,Lisa Dobbyn,Joy Schaefer,Natalie Silliman,Maria Popoli,Joshua T. Vogelstein,J.D. Browne,Robert E. Schoen,Randall E. Brand,Jeanne Tie,Peter Gibbs,Hui-Li Wong,Aaron S. Mansfield,Jin Jen,Samir M. Hanash,Massimo Falconi,Peter J. Allen,Shibin Zhou,Chetan Bettegowda,Luis A. Diaz,Cristian Tomasetti,Cristian Tomasetti,Kenneth W. Kinzler,Bert Vogelstein,Anne Marie Lennon,Nickolas Papadopoulos +46 more
TL;DR: A blood test that combines protein and DNA markers may allow earlier detection of eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA.
Journal ArticleDOI
Cancer-Associated Mutations in Endometriosis without Cancer
Michael S. Anglesio,Nickolas Papadopoulos,Ayse Ayhan,Tayyebeh M. Nazeran,Michaël Noë,Hugo M. Horlings,Amy Lum,Siân Jones,Janine Senz,Tamer Seckin,Julie Ho,Ren-Chin Wu,Vivian Lac,Hiroshi Ogawa,Basile Tessier-Cloutier,Rami Alhassan,Amy Wang,Yuxuan Wang,Joshua D. Cohen,Fontayne Wong,Adnan Hasanovic,Natasha L. Orr,Ming Zhang,Maria Popoli,Wyatt Mcmahon,Laura D. Wood,Austin Mattox,Catherine Allaire,James H. Segars,Christina Williams,Cristian Tomasetti,Niki Boyd,Kenneth W. Kinzler,C. Blake Gilks,Luis A. Diaz,Tian Li Wang,Bert Vogelstein,Paul J. Yong,David G. Huntsman,Ie Ming Shih +39 more
TL;DR: It is found that lesions in deep infiltrating endometriosis, which are associated with virtually no risk of malignant transformation, harbor somatic cancer driver mutations.
Journal ArticleDOI
Applications of liquid biopsies for cancer.
Austin Mattox,Chetan Bettegowda,Shibin Zhou,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein +5 more
TL;DR: This data indicates that liquid biopsies have the potential to detect, characterize, and monitor cancers earlier than is possible with conventional approaches.
Journal ArticleDOI
PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.
Austin Mattox,Jin-A Lee,William H. Westra,Robert H. Pierce,Ronald Ghossein,William C. Faquin,Thomas J. Diefenbach,Luc G. T. Morris,Derrick T. Lin,Lori J. Wirth,Armida Lefranc-Torres,Eiichi Ishida,Eiichi Ishida,Patrick D. Chakravarty,Lauren Johnson,Yang Zeng,Huabiao Chen,Mark C. Poznansky,Neil M. Iyengar,Sara I. Pai +19 more
TL;DR: The results highlight the importance of CD4+ TILs as pivotal regulators of PD-L1 levels and in determining the responsiveness of OTSCC to PD1-based immune checkpoint therapy.
Journal ArticleDOI
Ki-67 is required for maintenance of cancer stem cells but not cell proliferation
Justin Cidado,Justin Cidado,Hong Yuen Wong,D. Marc Rosen,Ashley Cimino-Mathews,Joseph P. Garay,Abigail G. Fessler,Zeshaan A. Rasheed,Jessica L. Hicks,Rory L. Cochran,Sarah Croessmann,Daniel J. Zabransky,Morassa Mohseni,Morassa Mohseni,Julia A. Beaver,David Chu,Karen Cravero,Eric S. Christenson,Arielle Medford,Austin Mattox,Angelo M. De Marzo,Pedram Argani,Ajay Chawla,Paula J. Hurley,Josh Lauring,Ben Ho Park,Ben Ho Park +26 more
TL;DR: It is demonstrated that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche, and Immunohistochemical analyses of human breast cancers revealed that Ki- 67 expression is maintained at equivalent or greater levels in metastatic sites of disease compared to matched primary tumors, suggesting that maintenance of Ki -67 expression is associated with metastatic/clonogenic potential.